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Group cognitive-behavioral therapy for insomnia: a meta-analysis. Background: insomnia is a highly prevalent disorder in the general population and in clinical practice. Although pharmacological treatment is the most widespread choice, psychological treatment appears to have longer lasting effects. The main objective of this meta-analysis was to assess the cognitive-behavioural group therapy treatment for insomnia. Adding up the data from all 9 trials, a total of people completed the post-test phase.
Results: after finishing cognitive-behavioural therapy, significant improvements regarding insomnia were found according to the Pittsburgh Sleep Quality Index and Insomnia Severity Index, sleep latency, wake after sleep onset and sleep efficiency. There were no significant improvements in total sleep time. Conclusions: the results from experimental studies on cognitive-behavioural therapy as an insomnia treatment clearly suggest a positive impact on symptoms, as assessed using both validated scales and sleep diaries.
Key words: Insomnia; cognitive-behavioural therapy; meta-analysis; clinical trial. En estos 9 estudios personas completaron el post-test. Resultados: aparecen mejoras significativas con el tratamiento cognitivo-conductual para el insomnio en las escalas Pittsburgh Sleep Quality Index e Insomnia Severity Index, en latencia del sueño, en tiempo despierto después de iniciar el sueño y define clean hands doctrine eficiencia del sueño.
No aparecen mejoras significativas en el tiempo total de sueño. Conclusiones: los resultados de los estudios experimentales sobre terapia cognitivo-conductual para el tratamiento del insomnio sugieren que esta tiene un claro impacto positivo sobre los síntomas, evaluados tanto mediante escalas validadas como mediante diarios del sueño.
According to the DSM-IV-TR Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revisionthe main characteristic of insomnia is difficulty initiating or maintaining sleep, or the feeling of non restorative sleep lasting for at least one month, which causes clinically significant distress or impairment in social, occupational or other important areas of functioning American Psychiatric Association, Although The above manual divides the sleep disorders into four big groups primary sleep disorders, those related to other mental disorders, disorders due to a general medical condition and substance-induced sleep disorderthese distinction have disappeared in the DSM-V American Psychiatric Association, The new edition of this manual has removed the insomnia classification "related to another mental or physical disorder" to what is the definition of phylogeny in biology causal attributions and allows to alert about any relevant comorbidity requiring independent clinical attention.
In this way, insomnia diagnosis includes primary insomnia, insomnia related to other mental disorders and insomnia due to a general medical condition. This new terminology was recommended by the NIH National Institutes of Health in and is being widely adopted by sleep experts. The suggestion is to make the diagnosis of "insomnia disorder" when the patient meets the insomnia criteria, regardless of the presence of other medical, psyquiatric or sleep disorders.
Insomnia is a highly prevalent disorder in the general population and in the clinical practice. It has been proven that more than a half of the primary care patients suffer sleep problems, particularly insomnia and hypersomnia Tubtimes, Sukying and Prueksaritanond, In the same study the results showed that Several epidemiologic studies on insomnia in the general population have shown high prevalence rates, but not many of them have applied the diagnostic criteria from the available classification manuals.
This makes it difficult to distinguish whether these subjects suffer from insomnia disorder or only insomnia symptoms. Patients with sleep difficulties have a what is the difference between cognitive behavioral therapy and behavioral therapy quality of life, more depression and anxiety symptoms, slower reaction times, poorer memory Hauri, and attention deficit Walsh et al. Of all the sleep disorders, insomnia, apnoea and restless legs syndrome have the greatest impact on concentration and memory Ram, Seirawan, Kumar and Clark, Patients with sleep problems are more predisposed to develop hypertension, depression and cardiovascular and cerebral vascular disease.
The same occurs the other way around, people with those health disorders have higher risk of suffering sleep problems Bloom et al. Despite the high prevalence of sleep disorders and their negative impact on daily life, evidence suggest that insomnia is underdiagnosed Ram et al. There are different recommended interventions in the bibliography for the treatment of sleep problems, but the most widely applied to treat insomnia are the pharmacological treatments Rosekind and Gregory, The American Academy of Sleep Medicine establishes that both pharmacological and behavioral treatments are effective in the short term, but, only the behavioral treatment maintains its effects long term.
However, there are few studies with follow-up periods longer than a year Bootzin and Epstein, The psychological therapies proposed for insomnia treatment include cognitive-behavioral therapy, which combines multiple approaches, such as sleep restriction, stimulus control or cognitive therapy. Both psychological and behavioral interventions are effective in treating chronic and secondary insomnia Mongerthaler et al.
Besides, regarding the type of patients, it has been proven that these therapies are also effective in elderly people and long term hypnotic consumers Mongerthaler et al. Finally, concerning treatment method, cognitive-behavioral therapy for insomnia has shown good efficacy in groups, individually or in self-help format Morin, Bootzin, Buysse, Edinger, Espie and Lichstein, In the last 20 years several meta-analyses and reviews have been published on results from psychological interventions in their different formats for the treatment of sleep problems Morin, Culbert and Schwartz, ; Murtagh and Greenwood, ; Harvey and Tang, ; Irwin, Cole and Nicassio, ; Van Straten and Cuijpers, ; Cheng and Dizon, These publications show results from different formats of psychological therapies for insomnia such as self-help Van Straten and Cuijpers, or computerized cognitive-behavioral therapy Cheng and Dizon, In most cases, the article selection was based on the description of certain symptoms by the authors, rather than on proper insomnia diagnosis van Straten and Cuijpers, In addition, many of them have excluded papers recruiting participants suffering from other mental or physical diseases Murtagh and Greenwood, or only selected those papers including samples of participants diagnosed with primary insomnia Irwin, Cole and Nicassio, In view of the characteristics of the published meta-analyses, we consider that a systematic review of the results from the psychological treatments in patients with an actual insomnia diagnosis, and not just with certain insomnia symptoms will be of interest.
In addition, considering the latest changes in the DSM diagnostic criteria, we find it appropriate to include all patients with insomnia in this meta-analysis, regardless primary or secondary diagnosis. The main objective of this meta-analysis is to assess the efficacy of cognitive-behavioral therapy in group format for the treatment of insomnia, be it primary or concurrent with other medical or psychological diseases.
To the best of our knowledge, this is the first meta-analysis with these characteristics. The literature search was performed using several data-bases. We also consulted with what is the difference between cognitive behavioral therapy and behavioral therapy in the field. The search was performed between January and February Articles were selected as they appeared resulting from the sequence of database search, how beautiful the world is quotes that they did not appear in a previous database search.
Of those, 9 met all the inclusion criteria to be part of the meta-analysis. The search strategies used for the different databases are shown in Table 1. To be part of the meta-analysis the reviewed articles had to meet the following criteria: 1 Randomized controlled clinical trials RCTs including clinical data relevant for meta-analysis, 2 RCTs including results from insomnia treatments, 3 with a cognitive-behavioral intervention group, 4 participants older than 18 years, 5 diagnosed with primary what is the difference between cognitive behavioral therapy and behavioral therapy secondary insomnia according to What is the difference between cognitive behavioral therapy and behavioral therapy, ICD International Classification of Diseases or ICSD International Classification of Sleep Disorders criteria, 6 written in either English or Spanish and 7 published between and Three different researchers collaborated in the review of the papers selected in the search.
Each paper was independently reviewed for inclusion criteria by at least 2 researchers. Discrepancies were solved by consensus. This process reduced the number of studies included in the review to 9 which met all the established criteria. The Kappa coefficient between the different researchers was. We also applied the Jadad scale to check the quality of the 9 studies included in the meta-analysis. This scale was applied by 2 researchers independently Jadad et al.
The score of this scale ranges from 0 to 5. Blinding is not achievable in this type of study due to the characteristics of the interventions, therefore the highest score possible was 3. The final score of these items was reached by consensus. Considering the 9 studies included in the review, participants finished the post-test phase, of which belonged to the cognitive-behavioral therapy group and to the control group.
We gathered data regarding the authors of the papers, date of publication, intervention used, groups size, age and sex of the participants, the duration of treatments, diagnostic criteria, the inclusion and exclusion criteria and the clinical data that we found relevant for the analysis, such as: sleep latency minutestotal sleep time hourswake time after sleep onset minutessleep efficiency, Pittsburgh Sleep Quality Index score and Insomnia Severity Index score post-test.
The extraction of relevant clinical data was performed two times totally independent from each other by two different researchers. Out of the values that formed the clinical data 4 were considered mistakes when we compared the results from both researchers. These mistakes were errors regarding the N value in some groups, which were solved by consensus after reviewing the original papers.
The authors of the selected publications were contacted to try to complete the information from the published papers, when considered insufficient. The statistical analyses were performed using the software program Epidat Xunta de Galicia y Organización Panamericana de la salud, Due to the characteristics of the selected variables, the option "standardized means difference" was chosen for the post-test analysis.
Firstly we performed a how to move contacts from phone to sim in iphone 6 analysis for all the variables DerSimonian and Laird's heterogeneity test followed by what is a causation in law statistical what is a composite number math antics incorporating heterogeneity random effects to assess the variance between studies the variance of the weighted mean of the effects from all studies multiplied by the number of studiesRI coefficient or the proportion of the total variance due to the variance between studies and variance within studies variance between studies divided by the weighted global effect mean.
Then we analyzed the combined results using the random effects model, which takes into account the heterogeneity in the analysis of the intervention effects. A reduction in the score of the two scales Pittsburgh Sleep Quality Index e Insomnia Severity Index is considered an improvement in sleep, as well as a reduction in the sleep lateny and in the wake after sleep onset value. However, for total sleep time and its efficiency, an increase in the score is considered an improvement.
Finally, we also analyzed the publication bias Begg and Egger testsas well as the sensitivity to assess the influence of any of the studies in the estimation of the global effect. In studies with more what is the difference between cognitive behavioral therapy and behavioral therapy 2 groups, we compared the cognitive-behavioral group with the what is the difference between cognitive behavioral therapy and behavioral therapy group.
It was not possible to find a variable that was present in all the studies for our statistical analysis. For this reason the N varied across the different variables studied. The literature search in the different databases rendered a total of papers. We rejected 97 because they did not meet all the inclusion criteria, 47 because they were not related to the main objective of the meta-analysis and 9 were accepted. Using the Jadad scale, we checked the quality of the studies included in the meta-analysis.
What is the difference between cognitive behavioral therapy and behavioral therapy of them scored between 2 and 3 and met the criteria of random allocation of the participants in the different study groups. Table 2 contains the main characteristics of the 9 studies that were included in this meta-analysis. The DerSimonian and Laird's heterogeneity test as well as the Galbraith graph indicated heterogeneity between the studies for all the analyzed variables except the Pittsburgh Sleep Quality Index.
For this reason, we used the random effects model for the combined estimation of the standardized mean differences. The heterogeneity analysis is detailed in Table 3. Table 4 shows the combined results, according to the random effects model, from the group cognitive-behavioral intervention for insomnia for the different variables assessed. Improvements were found for all of them excepting for the total sleep time. The same analyses were done splitting the studies into those which used a control group without any kind of intervention and those which did not do it in that way tables 5 and 6.
In addition, Figures show the forest plots for the different study variables. Regarding the presence of publication bias in the different variables studied, the p values from the Begg and Egger tests were. No statistical significance was found and, therefore, we dismissed the publication bias as a threat to the validity of the results from this meta-analysis.
We performed sensitivity analysis to assess the can b+ girl marry o+ boy of any of the studies in the global effect estimation. We did not find important changes in the results direction when we eliminated any of the studies. The results can be observed in Table 7. In this meta-analysis we compared the post-treatment results of cognitive-behavioral therapy for insomnia, in group format, with the results from different control groups, aiming to assess the efficacy of cognitive-behavioral therapy for this sleep disorder.
The different measurements employed across the studies reviewed made the N vary across variables and comparison of results difficult. After checking the inclusion criteria, 9 studies remained in the meta-analysis. The limited number of publications is precisely due to the inclusion criteria, since the more strict they are, the fewer studies remain in the analysis.
The number of studies included in this meta-analysis can be considered a limitation.
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