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Revista Española de Cardiología es una revista científica internacional dedicada a las enfermedades cardiovasculares. La revista publica en español e inglés sobre todos los aspectos relacionados con las enfermedades cardiovasculares. SJR es una prestigiosa métrica basada en la idea de que todas las citaciones no son iguales. SJR usa un algoritmo similar al page rank de Google; es una medida cuantitativa y cualitativa al impacto de una publicación.
Obesity is an important what does it mean when something is visceral risk factor and the location of fat deposits seems to be an important determinant of its metabolic impact. Visceral adipose tissue VAT exerts a harmful effect on metabolic homeostasis, but few longitudinal studies have evaluated the prognostic impact of the ratio of VAT to subcutaneous adipose tissue SAT. Registry-based retrospective cohort study. Eligible patients what does it mean when something is visceral of those without known heart disease referred to cardiac computed tomography What does it mean when something is visceral angiography to evaluate suspected coronary artery disease CAD.
We assessed the combined endpoint of all-cause mortality, myocardial infarction or revascularization procedure at least 1 month after cardiac CT. This ratio is a CT-derived metric that may help to better identify patients with increased risk of death or cardiac events. La obesidad es un importante factor de riesgo cardiovascular, y parece ser que la localización de los depósitos de grasa determina de manera importante su impacto metabólico.
Registro basado en estudio de cohortes retrospectivo. Se eligió para el estudio a pacientes sin enfermedad cardiaca conocida remitidos a coronariografía por tomografía computarizada TC por sospecha de enfermedad arterial coronaria EAC. Se evaluó el criterio de valoración combinado de mortalidad por todas las causas, infarto de miocardio o revascularización al menos 1 mes después de la TC cardiaca.
Obesity is a challenging global epidemic with at least one third of the adult population being obese. This was a registry-based retrospective cohort study using data from our Cardiovascular Diagnosis and Intervention Unit from a tertiary care hospital. The study sample was drawn from all patients who were referred for coronary computed tomography CT angiography for evaluation of coronary artery disease CAD from January to December Only patients from our primary catchment area were considered for this study.
We excluded patients with what does it mean when something is visceral cardiovascular disease previous myocardial infarction, stroke or revascularization procedure, valvular heart disease, previous myocarditis or cardiomyopathy or with serious life-threatening illness life expectancy less than 1 year. The what does it mean when something is visceral population included patients with full available data on abdominal adipose tissue areas and coronary artery calcium CAC score who were followed up for a maximum of 3 years Figure 1.
Patient selection flowchart. From the initial patients referred for cardiac CT due to suspected CAD, the final population included patients. The study protocol conformed to the ethical guidelines of the Declaration of Helsinki and was approved by the institution's ethics committee. All participants gave their written informed consent to participate in the study. Arterial hypertension was defined as history of hypertension according to the European Society of Cardiology Guidelines 17 or being on medical treatment with antihypertensive drugs.
Smoking history was classified as never, former participants who smoked for a minimum of can you reset on tinder months during their lifetime but did not smoke at study entry and current smoker. Type 2 diabetes mellitus was defined as a history of diabetes according to current worldwide consensus criteria 18 or being on medical treatment for diabetes.
Dyslipidemia was considered if the patient had a past history of dyslipidemia or was taking lipid-lowering drugs statins, ezetimibe or fibrates. To assess abdominal fat, a single-slice abdominal CT scan was performed between L4 and L5, according to the method described by Borkan et al. This resulted in an estimated radiation exposure of 0.
Image reconstruction of the calcium score acquisition was performed using an effective slice thickness of 3 mm. CAC score was reported as the mean Agatston score and was calculated using a detection threshold of HU using semiautomated software Syngo Calcium Scoring, Siemens Medical Solutions as described previously. In patients with body weight lower than 70 kg, tube voltage was reduced to kV. A bolus-tracking technique was used, with a region of interest placed within the ascending aorta, set to detect a predefined threshold of HU.
Severely calcified segments precluding lumen assessment were classified as positive for CAD. According to our department's policy, only patients from our primary catchment area were followed up in order to collect information on major acute cardiovascular events MACE. Patient follow-up data were collected by telephone interviews and electronic health record review at 12 and 36 months after cardiac CT. The combined endpoint included death from all causes, myocardial infarction or a revascularization procedure percutaneous coronary intervention or coronary artery bypass graft surgery at least 1 month after cardiac CT.
Myocardial infarction was defined according to the most recent consensus definition. Discrete variables are expressed as frequencies and percentages. Cox proportional hazards regression was used to perform the multivariate analysis using the following models: model 1 included age and sex; model 2 included age, sex, current smoking status, history of hypertension, type 2 diabetes mellitus, dyslipidemia, and familial history of premature CAD. Model 3 included all variables from model 2 plus coronary calcium score.
The proportional hazards assumption of the Cox models was evaluated with Schoenfeld residuals. One unit variation of the base-2 logarithmic transformation would be equivalent to a doubling of the variable of interest. All statistical analyses were conducted using Stata During a median follow-up of 1. The total event rate was 6. This association remained significant after adjustment for traditional cardiovascular risk factors model 2, adjusted hazard ratio, 1.
Visceral adipose tissue was not associated with the combined endpoint in the multivariate analyses Table 3. To our knowledge, this is the first longitudinal study to explore the influence of the relative distribution of abdominal fat between visceral and subcutaneous compartments on total mortality and incidence of what does it mean when something is visceral events. During the median follow-up of 1.
Our results are in agreement with a meta-analysis on how does blind date work association between CAD detected by CT angiography and cardiac events, including 32 studies and 41 patients over a mean follow-up of 1. Adipose tissue has been increasingly recognized as an important modulator of cardiovascular homeostasis. For example, during recent decades it was considered an abundant source of mesenchymal stem cells that produce several factors with angiogenic and immunomodulatory properties that might play a role in regenerative medicine targeting the heart.
Previous studies have shown that SAT may be associated with metabolic risk factors and increased insulin resistance, despite having a weaker association when compared with VAT. In this study, VAT was not an independent predictor of the combined endpoint. Our results support a protective role for SAT, what is an example of correlation and causation, according to previously published data, may be associated with improved insulin sensitivity and, therefore, a better metabolic profile.
Visceral adipose tissue affects not only metabolic homeostasis but also cardiac function, especially diastole. Increased VAT is associated with impaired diastolic function both in asymptomatic persons 31 and in those after a myocardial infarction. The limitations of this study include the observational design and caution should be exercised when drawing conclusions about causality. All decisions to proceed to myocardial revascularization were made by the attending simple binary form examples and cardiac surgeon.
We excluded revascularization procedures performed during the first month after coronary CT to avoid procedures that were prompted in the short-term what does it mean when something is visceral the result of the coronary CT angiography. Therefore, we can assume that most revascularization procedures were performed due to persistent angina despite anti-ischemic therapy or a positive ischemia test.
Our cohort included a white population, so its external validity, especially to other ethnic groups, remains to be shown. Only patients from our primary catchment area were followed up to accurately collect information on MACE. Those patients would necessarily come to our center if they had a MACE, and therefore we tried to reduce to a minimum the potential loss of information on MACEs that would be managed in best middle eastern restaurant los angeles centers.
A sensitivity analysis Table of the supplementary material showed no significant differences in age, sex, cardiovascular risk factors, calcium score, areas of abdominal fat, and prevalence of CAD between groups according to the presence or absence of 3-year follow-up information. In addition, we did not systematically collect detailed information about the medical drugs patients were prescribed. In addition to CAC quantification, this what does it mean when something is visceral may become clinically relevant by providing a tool to better identify patients with an increased risk of death and cardiovascular disease.
In the abdominal compartment, VAT seems to have a deleterious impact on cardiovascular health, but the role of SAT is less well established. This ratio may become a clinically relevant tool to better identify patients with an increased risk of death and cardiovascular disease. Revista Española de Cardiología. Artículo anterior Artículo siguiente. Léalo en español. DOI: Descargar PDF. Ricardo Ladeiras-Lopes ab. Autor para correspondencia.
Contenido relaccionado. Rev Esp Cardiol. Este artículo ha what does it mean when something is visceral. Información del artículo. Table 1. Table 2. Table 3. Introduction and objectives Obesity is an important cardiovascular risk factor and the location of fat deposits seems to be an important determinant of its metabolic impact. Methods Registry-based retrospective cohort study. We assessed the combined endpoint of all-cause mortality, myocardial infarction or revascularization procedure at least 1 month after cardiac CT.
This ratio is a CT-derived metric that may help to better identify patients with increased risk of death or cardiac events. Cardiac computed tomography. Introducción y objetivos La obesidad es un importante factor de riesgo cardiovascular, y parece ser que la localización de los depósitos de grasa determina de manera importante su impacto metabólico. Métodos Registro basado en estudio de cohortes retrospectivo. Se evaluó el criterio de valoración combinado de mortalidad por todas las causas, infarto de miocardio o revascularización al menos 1 mes después de la TC cardiaca.
Palabras clave:. Coronariografía how to start affiliate marketing on youtube tomografía computarizada. Texto completo. Figure 1. Figure 2. Figure 3.