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To determine the prevalence of hypotension and associated factors in hypertensive patients treated in the Primary Care setting. A cross-sectional, descriptive, and multicentre study was conducted with a total of general practitioners consecutively including 12, hypertensive patients treated in a Primary Care setting in Spain.
An analysis was performed on the variables of age, gender, weight, height, body mass index, waist circumference, cardiovascular risk factors diabetes, dyslipidaemia, smoking, obesity, sedentary lifestylefasting plasma glucose, complete lipid profile, as well as the presence of target organ damage left ventricular hypertrophy, microalbuminuria, carotid atherosclerosis and associated clinical conditions.
Hypotension was defined as a systolic blood pressure less than mmHg or a diastolic blood pressure less than 70 mmHg. A multivariate analysis was performed to determine the variables associated with the presence of hypotension. The mean age was The mean time of onset of hypertension was 9. A total of The prevalence of hypotension was higher in elderly patients The variables associated with the presence of hypotension included a history of cardiovascular disease, what does low diastolic reading mean treated with at least 3 antihypertensive drugs, diabetes, and what does low diastolic reading mean.
One out of 4—5 elderly patients, or those with cardiovascular disease, had hypotension. General practitioners should identify these patients in order to determine the causes and adjust treatment to avoid complications. Determinar la prevalencia de hipotensión y los factores asociados en pacientes hipertensos tratados en atención primaria.
Estudio transversal, descriptivo y multicéntrico; 2. Fueron analizados: edad, sexo, peso, altura, índice de masa corporal, perímetro de cintura, factores de riesgo cardiovascular diabetes, dislipidemia, tabaquismo, obesidad, sedentarismoglucemia en ayunas, perfil de lípidos, así como la presencia de daño en órgano diana hipertrofia ventricular, microalbuminuria, aterosclerosis carotídea y enfermedades clínicas asociadas.
La hipotensión se definió como presión arterial sistólica inferior a mmHg o presión arterial diastólica inferior a 70 mmHg. La antigüedad de la hipertensión fue de 9,1 años. Uno de cada pacientes de edad avanzada o con enfermedad cardiovascular tenía hipotensión. Los médicos generales deben identificar a estos pacientes para determinar las causas y ajustar el tratamiento para evitar complicaciones.
Therefore, achieving BP targets is mandatory in patients with hypertension. However, there are some relevant differences regarding the recommended BP goals between international clinical guidelines. However, some studies, such as the meta-analysis of Bangalore et al. However, the risk of severe hypotension and syncope was higher in those patients assigned to a stricter systolic BP target. On the other hand, different studies have shown that excessive BP reductions could be harmful in some patients.
At this moment, the possible what does low diastolic reading mean of a J-curve remains a topic of discussion. The J-curve implies that both high and excessively low levels of BP with antihypertensive treatment are associated with an increased what does low diastolic reading mean risk. Thus, it seems that there is a lowest value of BP nadirwhich represents a point at which BP is too low to maintain an adequate perfusion of vital organs. This is particularly important regarding diastolic BP and in patients with coronary artery disease.
By contrast, other studies have suggested that the J-curve could be different according to the type of organ, and consequently, the optimal BP to achieve for each organ. Moreover, other studies have questioned the existence of the J-curve. Achieving BP goals in hypertensive population without increasing the risk of side effects related with antihypertensive treatment should be one of the main objectives of general practitioners.
Hypotension related with antihypertensive treatment has not been clearly defined. To the best of our knowledge, no studies have specifically analyzed the prevalence of hypotension in hypertensive treated patients. The main objective of this study was to determine the prevalence of hypotension in hypertensive treated patients and the what is a complicated relationship associated with its development.
Clinical characteristics of the study population, the methodology and the definition of variables have been previously described. These data were collected from the clinical history of every patient. Biochemical data were recorded when blood tests were available within 6 months prior to inclusion. BP readings were taken according to current recommendations, with the patients in a seated position and their backs supported, after a 5 min rest, using calibrated aneroid or mercury sphygmomanometers or validated automatic devices, depending on the availability.
The patients were advised to quit smoking or drinking coffee within 30 min of BP assessment. Hypotension was defined as a systolic BP mmHg or a diastolic BP mmHg based on previous studies 17,18 that suggest that below these values the patients cardiovascular risk may be increasedand adequate BP control was defined as BP mmHg. The patients were asymptomatic, they came to the office to measure their BP in a routine way.
The presence of normal distribution was tested using the Kolmogorov—Smirnov test. In the bivariate analysis to compare 2 means, parametric Student t test or nonparametric Mann—Whitney U test statistical tests were performed based on the sample distribution. To compare percentages, the chi-square test or Fisher test was used, according to the sample size. To assess factors associated with the presence of hypotension, a logistic regression analysis was performed using those variables that reached statistical significance in the bivariate analysis.
Age, obesity, diabetes, chronic renal disease, sedentary life style, history of cardiovascular disease and polymedication were included as potential what does low diastolic reading mean factors in the analysis. Statistical significance was set at a p -value A total of 13, patients were included in the study. However, 3. As a result, 12, patients were finally analyzed mean age The prevalence of hypotension was similar between men and women From those patients with hypotension, The what does low diastolic reading mean of hypotension according to different clinical characteristics is shown in Table 1.
The prevalence of hypotension increased with age and with the presence of cardiovascular disease. The prevalence of hypotension was 7. Prevalence of hypotension according to different clinical characteristics. Mean values of systolic BP, diastolic BP and pulse pressure are described in Table 2 and the clinical characteristics of the study population according to the presence of hypotension, good BP control and poor BP control in Table 3.
Mean age of patients with hypotension was Patients with hypotension were older, had a lower body mass index and waist circumference, and a more favorable lipid profile. Smoking and sedentary life style were less frequent. By contrast, the presence of cardiovascular disease ischemic heart disease, stroke and renal insufficiency was more common. P : trend significance level between hypotension, good BP control and poor BP control. Clinical characteristics of the study population according to the presence of hypotension, good BP control and poor BP control.
In the multivariant analysis, independent factors associated with the presence of hypotension were history of cardiovascular disease, treatment with 3 or more antihypertensive drugs, renal insufficiency, diabetes and age. On the other hand, obesity and sedentary lifestyle were protective factors Table 4. Variables associated with the presence of hypotension. In this study, the prevalence of hypotension due to antihypertensive drugs in hypertensive treated patients attended in Primary Care setting was analyzed.
In the study of Verdecchia et al. To the what does low diastolic reading mean of our knowledge, this was the first study to analyze the prevalence of hypotension in this clinical setting. In fact, the prevalence of hypotension reported in clinical trials comparing different antihypertensive drugs was limited only to symptomatic hypotension.
As a result, the prevalence of hypotension reported in these studies may be lower than that observed in clinical practice, since many episodes of hypotension are not symptomatic and are detected when clinic BP is determined. The prevalence of hypotension was higher in elderly patients and in those patients with coronary heart disease. Importantly, excessive BP reductions could be more harmful in these patients.
With regard to elderly patients, in the study of Protogerou et al. In our study, the prevalence of hypotension was also higher in what is symbiotic relationship short answer with stroke, renal insufficiency and diabetes. Other studies have also described the existence of a J-curve in patients with diabetes 17,34 what does low diastolic reading mean renal insufficiency. Of note, what does low diastolic reading mean higher prevalence of high pulse pressure shown in is the internet more harmful than useful with hypotension and in those hypertensive subjects with uncontrolled BP when compared to patients with a good BP control could be related with the greater arterial stiffness observed in these patients with high systolic BP.
In this case, hypotension could be a consequence, particularly in elderly patients and in those with known cardiovascular disease. On the other hand, the presence of hypotension in elderly patients or in those with cardiovascular disease could also be related with the presence of other comorbidities, such as malnutrition, chronic conditions or cardiac dysfunction that may increase the mortality risk.
In the study of Gutiérrez-Misis et al. The presence of a J-curve remains controversial. Its existence could be related with the severity of some chronic conditions, or with a greater arterial stiffness and pulse wave velocity. In addition, it could be a marker of cardiac dysfunction or may limit myocardial perfusion, particularly when diastolic BP is excessively low. In contrast to coronary perfusion, cerebral perfusion depends mainly on systolic BP, but not on diastolic BP.
This could explain the dissimilar effects of the What is relationship bank account observed in different vital organs. Although our study cannot explain the pathophysiology of the J-curve, it showed that the prevalence of hypotension was more common in elderly patients and in those subjects with cardiovascular disease.
Our data suggest that hypotension could be a consequence in these patients. The prevalence of hypotension could also be related with the higher use of antihypertensive drugs in these patients and this with a greater difficulty to achieve BP goals in elderly patients. The higher systolic BP levels and the higher use of antihypertensive drugs may lead to excessive reductions of diastolic BP.
In addition, it also could be related with the greater efforts made by physicians to attain BP targets in patients with cardiovascular disease. In the multivariant analysis, the variables associated with the presence of hypotension included the history of cardiovascular disease, the intensive antihypertensive treatment 3 or more drugsdiabetes, and age. By contrast, sedentary life style and obesity were protective factors maybe because that what does low diastolic reading mean of the possible causes for this, is that the control of the BP is more difficult in obese patients.
Our study has some limitations. Thus, since a white-coat effect could occur in some patients, the prevalence of hypotension could be underestimated. In this context, ambulatory BP monitoring and home BP monitory could be very useful. In addition, although in this type of studies a possible bias could occur regarding the BP determination, a single BP value with two PA measurements to minimize the alert reaction, It shows the hypotension in a point in time and we do not know if it is maintained over time, but the large sample size of our study could reduce this potential limitation.
Another limitation of our study is the definition of hypotension chosen for our study.