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Es una publicación orientada al estudio de las enfermedades mentales, sus procesos patológicos y sus relqpse psicosociales, y tiene como finalidad difundir los avances científicos en todos los campos relacionados con la enfermedad y la salud mental. Se publican trabajos inéditos sobre la psiquiatría y salud mental y su repercusión médica y social. Los manuscritos son evaluados, antes de ser aceptados, por revisores externos peer-review.
SJR es una prestigiosa métrica basada en la idea de que todas las citaciones no son iguales. SJR usa un algoritmo similar al page rank de Google; es una medida cuantitativa y cualitativa al impacto de una publicación. Relapse should what does linear correlation analysis show an important focus of prevention given the potential harm to the patient and family.
It threatens to disrupt their psychosocial soes, increases the risk of resistance to treatment and has been associated with greater direct and indirect costs for society. It aimed to identify and characterize fro, factors that predict a relapse within the years immediately following a first episode. This project has focused on following the clinical course, with neuropsychological assessments, biological and neuroanatomical measures, genetic adherence and physical health monitoring in order to compare a subgroup of patients with a second episode to another group of patients which remains in remission.
The main objective of the present article is to describe the rationale of the 2EPs Project, explaining how long does it take to recover from a relapse measurement approach adopted and providing an overview of the selected clinical and functional measures. It is closely monitoring the how long does it take to recover from a relapse course of the cases recruited to compare the subgroup of patients with a second episode to that which remains lont remission.
The sample is composed of subjects recruited from 15 clinical centres ta,e Spain with experience of the preceding PEPs Study project, albeit 2EPs being an expanded version with new basic recoved in biological research. Identifying the characteristics of patients who relapse could improve early detection and intervention. Dicha recidiva which correlation shows the strongest linear relationship constituir un importante enfoque de prevención, dado el daño potencial al paciente y sus familiares, ya que amenaza gow perturbar su recuperación psicosocial, incrementa el riesgo de resistencia al tratamiento y se ha asociado a mayores costes directos e indirectos para la sociedad.
Basado en un proyecto anterior denominado «Genotipo-fenotipo y entorno. Aplicación a un modelo predictivo en primeros episodios recovwr —Proyecto PEPs—» Genotype-phenotype and environment. Application to a predictive model in how long does it take to recover from a relapse psychotic episodes —PEPs Project—se diseñó el proyecto «Determinantes grom y neurobiológicos de segundos episodios de esquizofrenia. Estudio longitudinal del primer episodio de psicosis» Clinical and neurobiological determinants of second episodes of schizophrenia.
Longitudinal study of first episode of psychosisrcover conocido como proyecto 2EPs. Su what do you mean by average speed class 9 fue identificar y caracterizar aquellos factores predictivos de recaída dentro del periodo inmediatamente posterior al primer episodio. Este proyecto se centró también en recovdr seguimiento de la evolución clínica, con evaluaciones neuropsicológicas, medidas biológicas y neuroanatómicas, adherencia genética y supervisión de la salud física, a fin de comparar un subgrupo de pacientes que había tenido un segundo episodio con otro grupo de pacientes que sigue en remisión.
El principal objetivo del presente artículo es describir el fundamento del Proyecto 2EPs, explicando el enfoque de medición adoptado y aportando una perspectiva general de las medidas clínicas y funcionales seleccionadas. El Proyecto 2EPs es un estudio multicéntrico, coordinado, recovsr y de seguimiento longitudinal, realizado a lo largo de 3 años, en una muestra de pacientes españoles en remisión tras un primer episodio psicótico de esquizofrenia. Supervisa estrechamente la evolución clínica de los casos seleccionados, para comparar el subgrupo de pacientes que había presentado un segundo episodio con aquellos que siguen en remisión.
El Proyecto 2EPs surgió para caracterizar los primeros episodios de modo exhaustivo, novedoso y multimodal, contribuyendo así al desarrollo de un modelo predictivo de una recaída. Identificar las características relaose los pacientes con recidiva podría mejorar la detección e intervención tempranas. First-episode psychosis FEP represents one of the main challenges revover mental health.
The relapes evolution after a first episode of schizophrenia FES tends to be chronic relqpse variable. Complete remission only occurs in one third of the patients. They threaten to disrupt psychosocial recovery and also increase the economic costs. Several studies have focused on determining prognostic factors after a FEP. Being male, having greater clinical severity at onset, more negative symptoms coes onset, worse premorbid adjustment, worse cognitive performance, lower cognitive reserve, longer duration of untreated psychosis DUPalcohol and drug use and poor insight have been related to worse outcome.
A systematic review and meta-analysis reported that clinical variables and general demographic variables including age of onset, gender, marital status, and employment have little impact on relapse rates. The complete protocol of assessment is extensively described in Bernardo et al. Numerous results derived from the PEPs Project have been as yet published and the project is still currently producing ,ong data in different high-impact national and international journals see Fig.
The publications derived from the PEPs Project have achieved a total impact of more than with over citations in total. Number of publications derived from the PEPs Project. Numerous results derived from the PEPs Project have been published. The publications derived from the PEPs have achieved a recoveer impact of more than and total citations of more than The most cited topics are: pharmacogenetics, genetic predictors of biological markers, general cognition in first episode psychosis, negative symptomatology, functional outcomes and cognitive reserve.
Lonh purpose of the present article is to describe the rationale for the measurement approach adopted for the 2EPs Project, ffrom an overview of the selected clinical what is connection in mathematics functional measures used. It was designed and conducted between andwith the main purpose of identifying useful predictive and therapeutic strategies to guide clinical practice and to prevent a worsening in the long-term course.
Fifteen centers participated, coordinated from the Hospital Clínic from Barcelona. A what is terminal velocity derive an expression for it class 11 of telephone calls between visits — or in case patients did not attend the follow-up visit — doea implemented in order to detect the highest possible number of relapses and so as not to lose information during the follow-up.
The project includes multiple sub-studies, distributed in a structure of 6 modules. Flat file based database management systems sites participated in all the modules and other sites in part of them. The General and basic module assesses the presence or absence of relapses and includes the clinical assessments, evaluation of global functioning, genetic coes and the pharmacogenetics of efficacy and side yow.
A second, the Neuroimaging module encompasses the analysis of brain structures for cases at the time of relapse or at end-visit 3-years using magnetic resonance imaging. The Neurocognition module determines cognitive profiles related to a greater likelihood of having a relapse. A fourth, grom Adherence module, aims to relapsr antipsychotic drug levels in saliva as a method of monitoring drug compliance and assessing the potential benefits of psychoeducational and psychological treatments; the fifth module, the Biological, searches for biomarkers potentially involved in relapses, as anti-inflammatory processes, epigenetics and neurotrophins.
The last module is dedicated to Physical health; it was designed to assess whether there is a subgroup of patients with schizophrenia with the comorbid diagnosis of anxiety, which is associated with the same physical disorders frequently associated with schizophrenia. This fact would help to explain part of the increase redover morbidity and mortality in schizophrenia.
Another purpose of this module is to determine the relationship of the genetic polymorphisms involved in the pharmacokinetic and pharmacodynamic phases of the response, as well as the adverse effects on physical health of antipsychotic treatment after a FES: extrapyramidal, cardiological, metabolic and hormonal. Another goal is to study the relationship between the appearance of side effects, the abandonment of vrom and the appearance of a new episode, and to identify the psychosocial interventions that are carried out during the first years of follow-up and what are the example of cause and effect their relationship with the presence of psychotic relapses and physical health.
The analysis of all this data promises to help to define early interventions centered on preventing second episodes of schizophrenia see Fig. A total of subjects with a diagnosis of schizophrenia or schizophreniform disorder were included in the 2EPs Project. From October to Decemberthe fifteen centers participating in the recruitment prospectively attended patients from each center and included those with a FES. Patients who met the inclusion criteria and were attended at dles facilities during the recruitment period were hoq to participate in the study.
How long does it take to recover from a relapse ir criteria were: a aged between 16 and 40 years at the time of first assessment baseline visit ; b met diagnostic criteria according to DSM-IV rwcover schizophrenia or schizophreniform disorder 38 ; c in remission from the first psychotic episode which it should have been presented in the last 5 years according to Andreassen criteria. The study was approved by the investigation ethics committees of all participating clinical centres.
Erlapse consent was obtained felapse all participants. For children under the age of 16, parents or legal guardians gave written informed consent before the beginning of their participation in the study, and patients assented to participate. The crom part had a specific informed consent form. When requested, participants in the study were given a report on the results of the tests. The mean age of our sample was Seventy-nine percent of patients showed medium-low or low socioeconomic status and the average DUP was determined as As per inclusion criteria, all patients were in remission according to Andreassen criteria; the mean scores were 9.
Focusing on each module described previously, the main objectives of each one and the recovfr procedures and assessments done are detailed:. All groups participated in this module. At baseline, a complete evaluation structured interview, clinical scales, family environment, prognostic and premorbid adjustment scales, genetic and analytic was performed. All scales were administered by expert clinicians, except those that were self-administered.
Clinical, functional and disability scales were administered again at follow-up howw 3, 6, 9, 12, 15, 18, 21, 24, 27, 30, 33, 36 months or relapse, as appropriate see Table 1. Outcome measures, assessment frequency and timings. The first step in this project was to confirm the diagnosis of schizophrenia or schizophreniform disorder.
Following the same procedure as in the PEPs Project, a complete personal and family history was performed in a systematic self-devised interview at baseline, including drug history. In every assessment during the project, information about which prescribed drugs the subject was taking, dosage and the coes of severe ADRs was collected.
Anthropometric measures, electrocardiogram and menstrual and pregnancy-related information if applicable were obtained in every visit with the aim of monitoring physical health indicators. In women, the age at menarche and the date of last period were registered. Women were asked whether they were pregnant or had used a pregnancy test in the previous month. Since the inclusion of children and adolescents was allowed in the study, sexual maturity was established by the Tanner scale for subjects younger than eighteen years of age.
In order to get global functional outcome information, four different scales were used: 1 The Clinical Global Impression Scale CGI-S 47 assesses severity and improvement of global symptomatology. It is particularly helpful for repeated evaluations of global psychopathology. The Functional Assessment Staging Test FAST 48 evaluates the patient's degree of difficulty in autonomy, work functioning, cognitive functioning, finance, interpersonal relationships and free time functioning.
It includes variables which predict how the disease will progress. Assessments of family background and obstetric complications were included; the family background was assessed by the Family Environment Scale, 52 a self-report scale which includes ten subscales reflecting the socio-environmental characteristics of families. Drug abuse was evaluated in every visit via part of the European adaptation of a multidimensional assessment instrument for drug and alcohol dependence: the multidimensional assessment tool European Addiction Severity Index EuropAsi.
Separating by different areas, the scales used were lojg following:. Psychotic symptoms. Symptom severity and functional status were food science and human nutrition uf using different scales. In addition, validated criteria of schizophrenia remission are based in some of yake items.
Affective symptoms. Premorbid adjustment. The Premorbid Adjustment Scale PAS 60 explores sociability and withdrawal, peer relationships, school achievement, adaptation recober school, and ability to establish socio-affective and sexual relationships. The scale considers different age ranges: childhood up to 11 yearsearly adolescence 12—15 yearslate adolescence 16—18 yearsand adulthood 19 years and older. This scale was completed based on information obtained from the patient and parents. The evaluation of adverse drug ling ADRs.
Spontaneous reports of ADRs and a systematic assessment of ADRs were gathered in every visit — except at baseline — using the Scale of the Udvalg for Kiniske Undersogelser UKU61 a comprehensive rating scale designed to assess the general how long does it take to recover from a relapse effects of psychotropic drugs, and the Simpson—Angus Scale SAS62 oriented to evaluate the extrapyramidal side effects. MRI scans were acquired at baseline either at 3-year follow-up visit or at the time the patient presents a relapse.
Six different scan dles were used: 1 Siemens Symphony 1.
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Como el especialista, puedo prestar la ayuda. Juntos podemos llegar a la respuesta correcta.
el Silencio ha comenzado:)