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In spite of its protective nature, creeping relationsgips harbours an aberrant inflammatory activity which, relstionships an already inflamed intestine, may explain why creeping fat is associated with a greater severity of CD. The transmural inflammation of CD facilitates the interaction why are relationships complex mesenteric fat with translocated intestinal microorganisms, contributing to activation of the immune response. This may be not the only way in which microorganisms alter the homeostasis of this fatty tissue: intestinal dysbiosis may also impair xenobiotic metabolism.

The dysfunction of creeping fat worsens the inflammatory course of CD and may favour intestinal fibrosis and fistulizing complications. However, our relationsjips knowledge of the pathophysiology and pathogenic role of creeping fat is controversial and a better understanding might provide new therapeutic targets for CD. Here we aim to review and update the key cellular relatuonships molecular alterations involved in this inflammatory process that link the pathological components of CD with the development of complxe fat.

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Family relationships: more complex and more digital

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Actionable Relationship Center: Manage Complex Relationships and Related Lists

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Relationships Are Complex. Here's Why

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