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The relationship between nutritional and how to tell if a system is linear factors and the likelihood of children in the Dominican Republic having a BCG scar. The Census information for the children included the presence of BCG scar, their nutritional status, and basic demographic data. We developed a new sociodemographic what is 4th base in a relationship, the "Rosa Index," to examine the potential influence of poverty and other environmental characteristics on scar presence.
We used logistic regression models to predict the presence of a BCG scar. Children in the areas what is 4th base in a relationship the country more than two hours' driving distance from the capital city of Santo Domingo more often what is 4th base in a relationship lower BCG scar prevalence levels than did children in Santo Domingo.
Nevertheless, the presence of a scar in a higher proportion of younger children suggests that coverage has improved in recent years. More programmatic and economic emphasis needs to be placed on extending early BCG vaccination coverage to the areas of the country where vaccination coverage is lower, and on examining the what is 4th base in a relationship role that poverty may have on vaccination effectiveness.
Key words: Tuberculosis, BCG vaccine, cicatrix, vaccination, population surveillance, socioeconomic factors, Dominican Republic. Se emplearon modelos de regresión logística para predecir la presencia de la cicatriz de BCG. Favorable outcomes of BCG vaccination have also been reported in the prevention of leprosy 8 and in the treatment of superficial bladder carcinoma 7. The presence or absence of a BCG scar is often used in clinical settings as an indicator of vaccine effectiveness, and the same is done in surveys carried out by EPI and other health programs in order to assess vaccine uptake 9.
However, What is 4th base in a relationship scar as a measure of vaccine coverage is still a subject of controversy. Discrepancies that are found in vaccine effectiveness can be explained by vaccine characteristics nonpotent BCG strain dose, or qualitypoor vaccination techniques, recipient characteristics e. The Dominican Republic has a high TB what is 4th base in a relationship rate, approximately 45 cases per inhabitants BCG vaccination has been carried out in accordance with WHO guidelines, under the aegis of the immunization program of the Ministry of Health.
Sinceintradermal administration of BCG has been recommended at birth in any hospital, health post, or other health facility. Sincethe same strain of BCG has been used across the country This study was conducted to assess nationwide BCG scar prevalence in Dominican children, and it also examined the relationship between nutritional and sociodemographic factors and the likelihood of having a BCG scar.
All children from 6 to 9 years of age attending public or private elementary school were included in the Census on Height and Weight. A trained school teacher interviewed the caregivers of the children, who accompanied the children to the school. The interviews typically lasted 30 minutes and were performed in a private classroom in the school.
A pretest was conducted with 50 schoolchildren from the different school regions of the Dominican Republic. There are 16 school regions in the Dominican Republic, with each region comprised of different provinces and municipalities Figure 1. The school regions were created by the Secretariat of Education to facilitate logistics food distribution, data collection, etc. As part of the training procedures, school teachers were instructed on how to recognize the BCG scar, perform anthropometric measures, and conduct the interviews.
Methods were standardized for filling out and reviewing the study forms. The teacher interviewers were trained to obtain measurements of height, using standard anthropometric methods. Height was calculated with a locally made centimeter measuring board placed on the wall at a degree angle, as recommended by the Pan American Health Organization.
The interviewer examined both of the child's arms for the presence of a BCG scar and recorded the scar's presence or absence on a data collection form. Basic demographic data age, sex, and place of residence school region of the what does gallus mean in latin were obtained, as well as information about the legal guardian's socioeconomic status.
Information about the school building, such as type of toilet, trash collection, and type of construction wood or cementwas also collected, and recorded on the data collection form. The Census on Height and Weight data included the prevalence of malnutrition by school region. A secondary data analysis of the BCG scar prevalence in Dominican children. This research was a correlational, secondary data analysis study intended to determine the effect of sociodemographic and nutritional parameters on the likelihood of having BCG scar.
We performed the statistical analysis of the collected data using SPSS Logistic regression models were also developed to predict the presence of a BCG scar. In each model, the category most positively associated with the presence of BCG scar was generally used as the reference category. To facilitate interpretation of the school data for univariate and multivariate models, the school regions were grouped into three geographic categories: 1 Santo Domingo reference groupwhich is the capital of the Dominican Republic; 2 school regions one to two hours' driving distance from the capital "Mid School Regions" ; and 3 school regions more than two hours' driving distance from the capital "Other School Regions".
The Rosa Index. To evaluate the impact of sociodemographic what is 4th base in a relationship variables on scar presence, a new quantitative sociodemographic indicator, the "Rosa Index," was developed by the main author E. The term "Rosa" was used to acknowledge the contribution of Rosa Urania Abreu in developing the index. This new approach assigned a possession score to every school region based on the mean values of monthly household income, as well as the mean proportional values of residential and schools characteristics for each region.
Possible index scores could range from zero minimum to 12 maximum. The higher the index score, what is 4th base in a relationship better the "ecological" characteristics of the school region. Multivariate analysis. For the multivariate analysis, variables were entered according to their statistical significance what is 4th base in a relationship univariate analysis and their biologic relevance.
Various models were evaluated, including a full model containing all the variables studied, in order to select the best possible model to fit the data. The goodness of fit of the logistic models was assessed taking into consideration the changes introduced into the log likelihood function. Alpha was set at 0. Ethical issues. The overall BCG scar prevalence found through the examination of the children's arms was Sociodemographic characteristics and BCG scar presence.
The characteristics of the children are shown, by gender, in Table 1. There was a similar presence of BCG scar among males and females. The univariate analysis showed associations between several variables and the presence of BCG scar Table 2. Another factor that was associated with scar presence was geographic location Table 2. In general, children living in Mid School Regions less than two hours' driving distance from the capital were more likely to have a BCG scar than were children living in Santo Domingo, the capital of the Dominican Republic reference category.
In contrast, children living in the Other School Regions more than two hours' driving distance from the capital were generally less likely to present a scar than were children living in Santo Domingo Table 2. The multivariate analysis used a full three-model variable since removal of each of the variables did not result in a different and significantly improved pattern to fit the data.
The multivariate analysis revealed the same pattern of significance observed in the univariate analysis, except for nutritional status, which no longer had a statistically significant affect on the scar's presence. The Rosa Index evaluated the impact of 12 environmental variables residence characteristics and school characteristics on scar prevalence. The highest score for a particular school region could be 12 points, and the lowest could be zero. The higher the Rosa Index score, the better were the "ecological" characteristics of the school region.
Several factors appeared to contribute to the lack of BCG scar presence. In evaluating these findings, it is worth recalling common limitations of correlational studies, particularly the inability to link exposure with disease in particular individuals The higher likelihood of malnourished children lacking a BCG scar raises the possibility that malnutrition negatively affects scar development through its impact on the immune system However, from our study, it was not possible to determine the schoolchildren's nutritional status in infancy how genetic therapy works to ascertain if there was a relationship between this variable and the presence of a BCG scar.
This highlights the importance of obtaining information regarding vaccination history in future census programs implemented in the Dominican Republic. A second major limitation is related to the representation of average exposure levels, rather than actual individual values. Thus, while it may appear from correlational data that there is an overall positive or negative association, this might actually be masking a more complicated relationship between exposure and disease 15in this particular what is 4th base in a relationship, vaccine administration and the presence of BCG scar.
Therefore, in this type of study design, malnutrition should be considered as an indicator of health inequalities rather than as a disturbance in a particular individual's immune system. The univariate and multivariate analyses indicate an interesting age-related pattern. Children from 7 through 9 years what is 4th base in a relationship age were less likely to have the BCG scar than were children 6 years of age. To some extent this may reflect changes in the quality of the BCG vaccination program e.
The higher proportion of young children with a BCG scar may also reflect a general improvement in vaccination coverage. Other factors at the individual or programmatic level could also be associated with this trend, and they need to be considered in future studies, in which the unit of analysis should be students, and not school regions. There were also statistical differences in scar prevalence according to geographical location school region.
Better access to the health care services in urban areas, greater availability of pediatricians, and inability of the Dominican EPI to cover all regions of the country, especially the very poor regions along the border with Haiti 17may also have contributed to this pattern. BCG coverage in Santo Domingo, the capital, was expected to be higher than in other areas of the country since a variety of factors affecting the probability of being vaccinated, including better socioeconomic conditions and improvements in public health policies, are present in this area.
However, children living in some of the school regions approximately one or two hours' distance from Santo Domingo were actually more likely to have a BCG scar than were children living in the capital. These unexpected results may be related to different logistic procedures of the Dominican EPI and to other, unknown factors inherent to those school regions that were not examined in this study and that will need to be considered in future research.
Why you shouldnt date right after a breakup increase understanding of other variables that could be impacting coverage, the Rosa Index, which included more "ecological" variables, was created. Nutritional status was only significant when the Rosa Index was what is the characteristics of media based arts in the multivariate model.
This finding suggests a potential role for poverty in vaccination effectiveness. It is important to note that a number of factors that were not represented in the Rosa Index could have had an important impact on scar presence. These factors include the type of legal guardian mother vs. Future census work in the Dominican Republic will need to evaluate multiple ecological factors in order to provide a broad perspective.
Consequently, the findings represent Dominican children between 6 and 9 years of age among different school regions of the country. The findings also overcome the limitations reported in previous, hospital-based surveys of What is 4th base in a relationship coverage implemented in the Dominican Republic 17, Nevertheless, we recognize that including additional variables related to EPI logistical procedures, children of different ages e. In summary, it appears that an appropriate goal for the Dominican health authorities would be to ensure that all children receive the what are common needs in a relationship afforded by the BCG vaccine.
The effectiveness of the Dominican EPI interventions needs to be monitored and to be measured in terms of community perceptions on such priorities as access to health care facilities and vaccine availability. Otherwise, community "ownership" of the EPI efforts is unlikely, and it is doubtful that the EPI objectives will be achieved, even though health care services are, in principle, available. Qualitative surveys could be included in the Census on Height and Weight, in order to learn what caregivers perceive as their priorities for increasing vaccination coverage, how vaccination programs fit into these priorities, and how the perceived priorities could be achieved within the context of the existing constraints such as poorer access to the what is 4th base in a relationship care services in rural areas and the inability of the Dominican EPI to cover the very poor regions of the country.
The authors thanks Dr. John Lewis for his statistical advice, and Dr. The authors also acknowledge the invaluable contribution of Rosa Urania Abreu in the creation of the Rosa Index, and Belkis Cuello for all her support. Lugosi L. Theoretical and methodological aspects of BCG vaccine from the discovery of Calmette and Guérin to molecular biology.