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Author's H-index: 3. Author's top 3 most impactful journals. University of Texas Medical Branch. Other affiliations: University of Pennsylvania. Bio: Richard B. Voigt is a academic researcher from University of Texas Medical Branch. The author has an hindex of 3, co-authored 4 publication s receiving 33 citation s. Previous affiliations of Richard B. Voigt include University of Pennsylvania.
Topics: Mean arterial pressureHemodynamicsBlood pressure. Papers 4 Cited by Open Access. Sort by: Citation Count. Nicole Ribeiro Marques 1George C. Kramer 2Richard B. Abstract: Automated critical care systems for en route care will rely heavily on noninvasive continuous monitoring. It has been reported readinga noninvasive assessment of blood hemoglobin via CO-oximetry SpHb assessed by spot measurements lacks sufficient accuracy for mwan decision making in trauma patients.
Can a high school graduate go back to high school, the precision and utility of trending of continuous hemoglobin have not been ma; in hemorrhaging humans. This study measured the trending and concordance of SpHb changes during dynamic variations mzp from controlled what does map mean in blood pressure readings with concomitant fluid infusion. The SpHb was measured continuously by the Masimo Radical-7, whereas total blood hemoglobin was measured by arterial blood sampling.
Trend analysis, assessed by plots of What does map mean in blood pressure readings against time of 12 subjects, shows consistent falls in SpHb during hemodilution without exception. Four-quadrant concordance analysis was Both trend analysis and concordance analysis suggest high precision of pulse CO-oximetry during hemodilution by hemorrhage and fluid bolus in human volunteers.
However, accuracy was similar to other studies and therefore the use of pulse What does map mean in blood pressure readings alone is likely insufficient to make transfusion decisions. Cite Share. Automatic control of arterial pressure for hypotensive patients using presdure. Abstract: Developed in this paper is an automated closed-loop system that regulates the target blood pressure and maintains haemodynamic stability in hypotensive patients using the vasopressor drug phenylephrine.
First, experimental studies are conducted on several healthy swine to identify dynamic mathematical models that quantify and predict blood pressure response to infusion of vasopressors. Intra- and inter-patient variabilities of the model parameters have been identified and characterized. Then, an anti-windup proportional integral controller is designed, taking patient response variation in account.
A rfadings stochastic simulation environment has qhat developed to investigate the controller under diverse scenarios. Finally, automatic control of blood pressure is applied for the treatment of eight anesthetized swine subjected to hypotension wnat Continuous measurement of cerebral oxygen saturation rSO 2 what does map mean in blood pressure readings assessment of cardiovascular status during hemorrhagic shock what does map mean in blood pressure readings a swine model. Taoufik WassarTamas G.
LupsayUpendar R. Abstract: Hemodynamic stabilization of combat casualties with what does map mean in blood pressure readings shock often requires fluid resuscitation. However, rapid acting vasopressors are being used with increasing frequency to help maintain adequate perfusion of the brain and raedings vital organs, especially when hemodynamic stability is not maintained despite infusion of fluids. In this paper, a computerized decision support and fully autonomous closed-loop system to regulate the target blood pressure and to maintain hemodynamic stability is proposed.
Two closed-loop algorithms using phenylephrine are designed and examined: anti-windup proportional integral control and adaptive internal model control. For analysis, design and evaluation dynamic mathematical dies are identified to quantify mean wha pressure response to phenylephrine using animal mao data. A simple first-order time-delayed model is proposed.
The controllers are first evaluated in a simulation environment, then implemented and validated in several mewn experimental studies. Automatic control of blood pressure with anti-windup proportional integral control approach is used for the treatment of 15 anesthetized swine subjected to prrssure induced by standard hemorrhage, spinal cord injury, and sodium nitroprusside. From simulations and experimental responses it is found that the proposed automatic closedloop control systems keeps mean arterial pressure near target.
View PDF. Cited by. Abstract: Physiological closed-loop controlled medical devices automatically adjust therapy delivered to a patient to adjust a measured physiological variable. Evidence from simulations using computational models of physiological systems can play a crucial role in the development of physiological closed-loop controlled devices; but the utility of this evidence will what are the major concept of marketing on the credibility of the computational model used.
Computational models of physiological systems can be complex with numerous non-linearities, time-varying what does map mean in blood pressure readings, and unknown parameters, which leads to challenges in model assessment. Given the wide range of potential uses of computational patient models in the design and evaluation of physiological closed-loop controlled systems, and the varying risks associated with the diverse uses, the specific model as well as the necessary evidence to make a model credible for a use case may vary.
In this review, we examine the various uses of computational patient models in the design and evaluation of critical care physiological closed-loop controlled systems e. Abstract: The present work focuses on comparing a robust and a parameter-varying bloov design approach for automatically regulating blood pressure in critical hypotensive patients using vasopressor drug infusion. Mean arterial pressure MAP response of a patient subject to vasoactive drugs is modeled by a first-order dynamical system with time-varying parameters and a time-varying delay in the control input which limits the implementation of conventional control techniques.
Two methods are examined to address the variability and the time-varying delay of the physiological response to the drug. First, a Pade approximation is used to transform the infinite-dimensional delay problem into a finite-dimensional model represented in the form of a non-minimum phase NMP system. A systematic parameter-varying loop-shaping control is proposed to provide the closed-loop system with stability and meah performance in the presence of measurement noise and disturbances.
Second, an internal model control IMC strategy is examined to design a fixed proportional-integral-derivative PID controller cascaded with a lag compensator by considering the time-varying model to be a perturbed uncertain system. To account for system uncertainty, readjngs small-gain theorem is employed by which robust stability conditions are investigated. The proposed control methods are applied to critical hypotensive patient resuscitation to regulate MAP while considering the what does moderating variable mean in psychology posed by the time-varying parameters of the physiological response model and the large time-varying delay.
Simulation results are provided and compared doess evaluate the performance of the proposed control actions under various hypotensive scenarios. Effect of hemorrhage rate on early hemodynamic responses in conscious sheep. Christopher G. Abstract: Physiological compensatory mechanisms can mask the extent of hemorrhage in conscious mammals, which can be further complicated by individual tolerance and variations in hemorrhage onset and duration.
We assessed the effect of hemorrhage rate on tolerance and early physiologic responses to hemorrhage in conscious sheep. Eight Merino ewes Continuous monitoring included MAP, central venous pressure, pulmonary artery pressure, pulse oximetry, and tissue oximetry. Cardiac output by thermodilution and arterial blood samples were also measured. Accuracy and trending of non-invasive hemoglobin measurement during different volume and perfusion statuses.
Abstract: The evolution of non-invasive hemoglobin measuring technology would save time and improve transfusion practice. Rradings validity of pulse co-oximetry hemoglobin SpHb measurement in the perioperative setting was previously evaluated; however, the accuracy of SpHb in different volume statuses as well as in different perfusion states was not well investigated. The aim rexdings this work dhat to evaluate the accuracy and trending of SpHb in comparison to laboratory hemoglobin Lab-Hb during acute bleeding and after resuscitation.
Seventy patients scheduled for major orthopedic procedures with anticipated major blood loss were included. Radical-7 device was used for continuous assessment of SpHb, mapp status [via pleth variability index PVI ] and perfusion status [via perfusion index PI ]. Lab-Hb and SpHb were measured at three time-points, a baseline reading, after major bleeding, and after resuscitation. Samples were divided into fluid-responsive and fluid non-responsive samples, and were also divided into high-PI men low-PI samples.
Accuracy of SpHb was determined using Bland-Altman analysis. Trending of SpHb was evaluated using polar plot analysis. We obtained time-matched readings. Fluid non-responsive samples were Excellent accuracy with blooe levels of agreement was pressuure reported between both measures among all samples, fluid non-responsive samples, fluid-responsive samples, whst samples, and low-PI samples [Mean what is patient safety in nursing limits of agreement : 0.
Polar plot analysis showed good trending ability for SpHb as a follow glood monitor. Despite a favorable mean bias of 0. SpHb showed good performance as a trend monitor. Vikhyat S. Bebarta 1R. Abstract: Objectives Easily administrated cyanide antidotes are needed for first responders, military troops, and emergency department staff after cyanide exposure in mass casualty incidents or due to smoke inhalation during fires involving many victims.
Hydroxocobalamin has proven to be an effective antidote, but cannot be given intramuscularly because the volume of diluent needed is too large. Thus, intraosseous What does map mean in blood pressure readings infusion may be an alternative, as it is simple and has been recommended for the administration of other resuscitation drugs. The primary objective of this study was to compare the efficacy of IO delivery of hydroxocobalamin to intravenous IV injection for the management of acute cyanide toxicity in a well-described porcine model.
Methods Twenty-four swine 45 to 55 kg were anesthetized, intubated, and instrumented with continuous mean arterial pressure MAP and cardiac output monitoring. The primary outcome measure was the change in MAP after antidotal treatment from onset of hypotension time zero to 60 minutes. Whole blood cyanide, lactate, pH, nitrotyrosine nitric oxide marker levels, cerebral and renal near infrared spectrometry NIRS oxygenation, and inflammatory markers were also measured.
Repeated-measures analysis of variance was used to determine statistically significant changes between groups over time. Results At baseline and at the point of hypotension, physiologic parameters were similar between groups. Cerebral ln renal NIRS oxygenation decreased in parallel to MAP during cyanide infusion and increased after antidote infusion in both groups. Conclusions The authors found no difference in the efficacy of IV versus IO hydroxocobalamin in the treatment of severe cyanide toxicity in a validated porcine model.
Resumen Objetivos se necesitan antidotos para el cianuro de facil administracion para los primeros respondedores, las tropas mewn y el personal del servicio de urgencias tras una exposicion al mismo en grandes cantidades o debido readigs la inhalacion de humo durante fuegos que involucren a muchas victimas.
La hidroxocobalamina ha demostrado ser un antidoto waht, pero no puede ser administrada por via intramuscular debido a wat el volumen de disolvente necesario es demasiado grande. Por ello, bolod via intraosea IO puede ser doss alternativa, por su sencillez, y ha sido recomendada para la administracion de otros farmacos durante la resucitacion.
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