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David Rodríguez 2 3. Jathniel Panneflek 3. Mario A. Fabiani 1 2. Juan Quintanilla 1 2. Luis Manautou 1 2. Erasmo de la Peña-Almaguer 1 2 3. Arturo Cadena 1 2. Gabriela Cassagne 2. Guillermo Torre-Amione 1 2 3 4. Fast-track worldwide reperfusion programs improve outcomes in ST-elevation myocardial infarction and stroke.
Fast-track stratification, diagnostics, and treatment min to improve proximal DVT and submassive and massive PE patients care. Increase diagnosis rate of low-risk PE and distal DVT; exploration of cause; long-term anticoagulation; identify high-risk profile for chronic complications; community-based support groups and patient education to extend the concept of the thrombosis-free hospital to thrombosis-free home. The team includes cardiologists, vascular medicine, angiologist, echocardiographer, cardiovascular imaging, and interventional cardiologists.
The team will be accessible 24 h a day, 7 days a week, days a year, and base on previous national experience. The cardiology fellow on call will be responsible for activation and evaluation. We will design several tools to accelerate these processes. Risk stratification and therapeutic approach will be based on clinical presentation, echocardiogram, and biomarkers findings.
Finally, establishing a network in our hospital and health system to improve VTE patients care. To the best of our knowledge, this is the first rapid response team focused on VTE in Mexico. Key words Venous thromboembolism; Pulmonary embolism; Deep vein thrombosis; Rapid response teams; Program evaluation and review technique; Mexico. Programas de reperfusión mejoraron la evolución en infarto con elevación del ST y accidente cerebrovascular embólico.
Estratificación, diagnóstico y tratamiento acelerado minutos para mejorar atención del TVP proximal y TEP masiva o submasiva. Incrementar diagnóstico de TEP de riesgo bajo y TVP distal; explorar causa; anticoagulación a largo plazo; perfil de riesgo alto para complicaciones crónicas; grupos de soporte en la comunidad y educación para pacientes, y extender el concepto de hospital libre de trombosis a hogar libre de trombosis. Incluye cardiólogos, medicina vascular, angiólogo, ecocardiografistas, imagen cardiovascular.
Diseñamos herramientas para acelerar el proceso. En nuestro hospital y sistema de salud establecer una sólida red de trabajo para mejorar la atención. Venous thromboembolism VTEincluding deep venous thrombosis DVT and pulmonary embolism PEis a worldwide disease characterized by cardiovascular mortality, impaired quality of life and significant long-term complications such as recurrence, a chronic thromboembolic pulmonary disease with or without pulmonary hypertension, and post-thrombotic syndrome PTS 1.
PE — the most severe consequence — is the third cause of cardiovascular mortality after myocardial infarction and stroke, the leading preventable cause of death in hospitalized patients, the main cause of pregnancy-related maternal death in developed countries, and the second cause of mortality in cancer patients 1. Furthermore, VTE is the third most common complication in trauma patients, and PE is the third most common cause of death in patients who survive the first 24 h after injury 2.
PE survivors commonly have persistent right what are examples of effective team dynamics american heart association dysfunction, impaired functional status NYHA Class II—IVdiminished exercise capacity 6-min walk testand reduced quality of life in the follow-up 3. In addition, 3. Despite this evidence, advanced therapies to reduce PTS incidence are not carried out expeditiously.
Recently, Heart Teams are launched to improve the management of complex cardiovascular diseases 8including PE patients. Inthe Massachusetts General Hospital MGH created the first formal and successful multidisciplinary rapid-response team, called program evaluation and review technique PERTto assess and provide clinical recommendations for patients with submassive and massive PE in real time 9. Worldwide institutions reproduced similar concepts, mobilizing multidisciplinary teams that coordinate and provide optimal therapeutic options, which in turn improve patient care Primary objective: to provide fast-track stratification and diagnostics min after protocol activation to initiate anticoagulation alone promptly or anticoagulation plus advanced therapy systemic or mechanical thrombolysis in submassive, massive, and proximal DVT.
The decision-making between anticoagulation alone or advanced therapy will be by an experienced clinician and depends on the extension of the thrombus burden and right ventricular dysfunction severity. The what are some easy things to bake team includes physicians trained in cardiology, vascular medicine, angiology, echocardiography, cardiovascular imaging, and interventional cardiology.
Furthermore, effective coordination and communication will be mandatory for a meaning of force in urdu program Fig. The team must be easily accessible and provide a consistent, rapid, and effective what are examples of effective team dynamics american heart association response in the emergency room, intensive critical care unit, or in-hospital setting.
VTE: venous thromboembolism. Table 1 shows the principal steps and the staff involved in the execution of the program. The first step of activation, which is based on clinical presentation sudden dyspnea, near or syncope, chest pain what are examples of effective team dynamics american heart association as angina, respiratory distress, and hypoxemia suggests submassive or massive PE 13 or proximal DVT leg pain and swelling.
Therefore, the hospital staff must know the VTE risk factors and how to identify high-clinically suspicious patients. Before the official what are examples of effective team dynamics american heart association, we will conduct educational programs, round table discussions, and case simulations geared toward hospital physicians, nurses, residents, students, and technicians. Furthermore, patient education will be mandatory to improve the outcome and reduce recurrence and bleeding complications in the follow-up.
An activation line will be available 24 h a day, 7 days a week, and days a year. The cardiology fellow on call will be responsible for the protocol activation, immediate patient evaluation, and obtain imaging and laboratory studies to accelerate the diagnostic process and save time. This information will be present during an online meeting. The checklist called S 2 HIELD B S signs and symptoms, H history, I image, E Electrocardiography, L laboratory, D demographics, and B bleeding risk provides the team with the necessary information to establish a high-clinical suspicion, diagnosis, bleeding risk, and decision-making Table 2.
Risk stratification will be base on clinical presentation, echocardiogram, and biomarkers findings. Imaging techniques and or ultrasound will prove the final diagnosis. The team will be ready to hold an online conference as soon as possible 30 minproviding the on-call fellow enough time to assess the patient and obtain enough data to prove VTE accurately and PE diagnosis, quantify the venous thrombus burden and assess right ventricular dysfunction severity. Finally, within min of the initial call, a treatment recommendation will be issued to the physician in charge.
The program will follow-up on the clinical condition, treatment response, and in-hospital complications to consistently improve patient care. All information, including clinical data, risk factors, clinical presentation, electrocardiogram ECGchest X-ray, biomarkers, diagnosis studies, as well as, therapeutic approach, will be captured in an electronic database. On discharge, patients will have a follow-up in the outpatient clinic if the health-care team deems it necessary.
We considered min as a window based on 1 our previous experience 14 - 20in which we perform stratification, diagnosis, and systemic thrombolysis in the first 90 min after PE patients arrive at the emergency room 15 ; 2 thrombus resistance 21right ventricular ischemia, and myocardial infarction 17 are all time-dependent; and finally, 3 evidence from mechanical and pharmacological reperfusion in ST-elevation myocardial infarction and ischemic stroke programs 1122 - Furthermore, we will activate the cardiac catheter lab and transesophageal echocardiography units in specific cases.
This evidence suggests that a rapid response team can modify in-hospital outcomes in a group of patients with high mortality risk. The foundation of VTE treatment is anticoagulation, and advanced therapy is the option in impending or clinically unstable patients. Table 3 112627 shows anticoagulation options in the acute phase, long-term, and extended phase. Unprovoked VTE, recurrence, active cancer, proved or strong suspicion of thrombophilia and a persistently abnormal D-dimer required long-term anticoagulation.
In patients with DVT with or without PE, we suggest low-molecular-weight heparin, enoxaparin instead of unfractionated what is a negative relationship in economics. Furthermore, non-Vitamin K antagonist oral anticoagulants are effective and possess a safer profile compared to Vitamin K antagonists Table 3.
Anticoagulation alone is recommended in low-risk PE patients clinical stability, no biomarkers expression, without severe right ventricular dysfunction, and moderate thrombus burden ; the route of administration regimen and type will be up to the preference of the physicians in charge. In the extended phase, the low-molecular-weight heparin, enoxaparin, is indicated in active cancer patients.
We recommend enoxaparin in low-risk PE patients starting with an intravenous bolus, except in what are the 5 types of stems patients in whom a dose reduction is mandatory Table 3 Loading apixaban or rivaroxaban doses are an effective and safe option in low-risk PE patients. In intermediate-risk, also called submassive PE, we recommend weight-adjusted unfractionated heparin for the first h, over enoxaparin to avoid heparin crossover if clinical status worsens.
The use of what are examples of effective team dynamics american heart association heparin as adjunctive treatment with a posterior switch to enoxaparin is a worldwide recommendation. This regimen was effective and safe, without intracranial hemorrhage in Mexican PE patients submitted to systemic thrombolysis Table 3 Parenteral and oral anticoagulants 1126 Although there are not recommendations to systemic thrombolysis in iliofemoral DVT patients 26we recommend the purpose of cause and effect diagram thrombolysis with alteplase at a dose of 0.
This therapeutic approach could reduce thrombus burden and venous hypertension, restore venous permeability, rescue limb in case of ischemia, and decrease PE risk. We also recommend percutaneous mechanical or pharmacomechanical thrombolysis. Various percutaneous devices are available with different mechanical principles for the removal of clot or thrombolysis: suction, rotation, rheolytic thrombectomy, and ultrasound 28 - The pharmacoinvasive approach combines the mechanical method and pharmacologic therapy to achieve thrombolysis This approach has shown to be effective with a lower dose of the thrombolytic drug and shorter procedural time with no difference in major bleeding or recurrence These filters should be removed as soon as possible When DVT occurs in the left iliac vein, we encourage the use of intravascular ultrasound to diagnose iliac compression May-Thurner syndrome If an iliac obstruction, residual thrombus or iliac stenosis is observed, angioplasty and dedicated vein stents use must be considered to improve patency Table 4 Anticoagulation and advanced therapy in venous thromboembolism patients 11263637 International and national guidelines 2627 - 38 recommend unfractionated heparin as adjunctive treatment and systemic thrombolysis in a well-selected Table 5 11 high-risk or massive PE patient IIb.
European and American College of Chest Physicians 2737 recommendations are against thrombolysis in what are examples of effective team dynamics american heart association high-risk or submassive PE patients because of what are examples of effective team dynamics american heart association increased rate of intracranial hemorrhage The PEITHO study 40 and additional previous evidence have shown in-hospital improvement outcome, with systemic thrombolysis 14161719 in this group.
Considering current and previous evidence, we recommended what is a non proportional relationship equation unfractionated heparin as adjunctive treatment and systemic thrombolysis IIB in a well-selected high-risk or massive PE patient. We recommend half dose short-term alteplase infusion Table 4instead tenecteplase in patients over 60 years considering the high incidence of intracranial hemorrhages, especially in female patients.
At present, to the best of our knowledge, half dose short-term alteplase infusion has no evidence of intracranial hemorrhage in the elderly population Avoid unnecessary venous or arterial punctures to reduce major or minor bleeding complications. Table 5 Absolute contraindications for thrombolysis We recommend pharmacoinvasive therapy in patients with intermediate- or high-risk bleeding complications since this therapeutic approach showed efficacy and safety in the Mexican population Recently, the OPTALYSE trial 42 significantly reduced alteplase dose and procedure time compared with previous ultrasound-facilitated catheter-directed thrombolysis studies 4344 Table 6.
Although alteplase 2 mg in 2-h short infusion had no major bleeding complications in a broad clinical PE spectrum, including submassive PE patients, we will recommend 4 what are examples of effective team dynamics american heart association to obtain a better reperfusion 42 Table 4. Finally, we recommend temporary inferior vena cava filters in patients with absolute contraindications for anticoagulation and thrombolysis in probed proximal DVT with or without in-transit thrombus patients 11 Table 4.
Table 6 Therapeutic alternatives in high-risk bleeding patients 11 Patent foramen oval PFO and clinical or subclinical paradoxical cerebral or systemic emboli are frequent and an underestimated complication in submassive and massive PE patients Hemorrhagic transformation of subclinical ischemic stroke 45 could explain unexpected intracranial hemorrhages after anticoagulation alone or advanced therapy in PE patients.
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