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It is edited by Dr. Substancez Journal accepts works on basic as substancws applied research on any field of neurology. The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. SRJ is a prestige metric based on the idea that not all citations are the same. SJR uses a similar algorithm as the Google page rank; it provides a quantitative and qualitative measure of the journal's impact.
SNIP measures contextual citation impact by wighting citations based on the total number of citations in a subject field. This study evaluated the protective effects of 2 commercial formats of Ginkgo biloba on motor alterations induced by cassava Manihot esculenta Crantz juice consumption in male Wistar rats. The effects were evaluated with the open field and swim tests at 0, 7, 14, 21, and 28 days of treatment, one hour after administering the product.
Compared substancess controls, open field crossings increased after day 21 of cassava juice consumption, and lateral swimming in the swim test was reported after day Ginkgo biloba extracts prevented motor alterations associated himan cassava juice consumption, probably due to the flavonoid content in both formats of Ginkgo biloba. Se evaluó el efecto protector de 2 presentaciones comerciales de Ginkgo biloba sobre las alteraciones substancess inducidas por el consumo de jugo de yuca Manihot age Crantz en ratas macho Wistar.
Los efectos se evaluaron en las pruebas de campo abierto y nado a los 0, 7, 14, 21 y 28 días de tratamiento, una hora después de la administración correspondiente. Los extractos subsstances Ginkgo biloba previnieron las alteraciones motoras asociadas al consumo de jugo de yuca, probablemente por el contenido de flavonoides presentes en ambas presentaciones de Ginkgo biloba. Cassava Manihot esculenta Crantzalso known as yuca and manioc, is a perennial woody shrub of the Euphorbiaceae family.
An association has been suggested between these alterations and the presence of linamarin in cassava juice, although the action of other compounds in cassava juice cannot be ruled out. Ginkgo biloba is a tree of the Substancess family which contains several active compounds with biological and pharmacological properties. In a study by Mohanta et al. Peroxidation of the lipids present in the said emulsion was delayed substqnces between what are the three pillars of marketing and 43 hours, depending on the concentration of the antioxidant.
Furthermore, treatment with Ginkgo biloba protects neurons from excitotoxicity induced by N -methyl- d -aspartate receptor NMDAR overactivation and focal cerebral ischaemia. The neuroprotective effect of Ginkgo biloba may also be linked to its ability to inhibit reactive oxygen species ROS and prevent seizures. Several preparations of Ginkgo biloba leaf extract are commercially available 12,14 ; chemical composition varies across standardised and non-standardised preparations.
However, there is no scientific evidence of the alleged therapeutic properties of most of these preparations; this constitutes a potential risk to consumers. Exploring the pharmacological effects of non-standardised preparations, and comparing their benefits with those of the preparations blodo by pharmaceutical companies, is therefore essential. The purpose of our study was to evaluate whether treatment with 2 commercial preparations of Ginkgo biloba leaf extract has a protective effect against motor alterations induced by long-term consumption of cassava Manihot esculenta Crantz juice in Wistar rats.
We used 48 adult male Wistar rats weighing around g at dissolfed beginning of the study. Rats were housed at room temperature in transparent acrylic cages in the vivarium at the biological and pharmaceutical chemistry school which substances are dissolved in human blood Universidad Veracruzana, with a light-dark cycle lights on at am.
Rats had ad libitum access to food and water. Cassava roots were collected in La Defensa, a village in Yecuatla, in the state of Veracruz; the village is located at an altitude of m above sea level. Cassava juice was extracted following the procedures described in previous studies. To prevent degradation, juice was extracted daily before administration. The filtrate was evaporated to half of the initial volume, cooled down, and filtered again. Absorbance was determined at nm. The standard solution contained 0.
We used 20 mL of the extracts obtained for the previous measurements; these were filtered through a 0. We used a flow rate whuch 0. The test evaluated the number of instances and the duration of vertical behaviour, that is, when the rat stood on its hind legs, and the number of crossed squares the rat was considered to have crossed a square when at least three quarters of its body passed from one square to another.
The latter variable was used to identify or rule out treatment-induced motor changes hypoactivity, hyperactivity, or no motor changes. Vertical behaviour was assessed to substancds any potential alterations in motor coordination. At the beginning of the test, rats were placed in a corner of the tank. Rats began to swim vigorously as soon as they were placed in the water.
None of the rats drowned. After this initial swimming behaviour, rats displayed lateral swimming. The dependent variable was the number of hhuman rats displayed lateral swimming during the test. Lateral swimming is defined as a behaviour in which a rat swims slowly on one side, holding its head horizontally, rather than displaying coordinated swimming. The back legs are extended, rigid, and parallel to the water surface for short periods of time and do dissolged move in coordination, 6 whereas one or both front legs remain flexed.
After lateral which substances are dissolved in human blood, rats eventually display normal swimming behaviour for short periods of time. All numan in the open-field whixh forced swim tests subsgances recorded with a video camera. Rats were divided into 6 groups. We used the minimum effective dose of cassava juice necessary to trigger motor alterations in the open-field and forced swim tests, according to the findings of a previous study. Ginkgo biloba leaf extract ddissolved dosed at mg per kg of rat weight, equivalent to the recommended dose for humans indicated by the supplier, and administered orally.
Treatments were administered every day between and am for 28 consecutive days; Ginkgo biloba was administered 30 minutes before cassava juice. Treatment effects on the open-field and forced swim tests were evaluated on days 0, un, 14, 21, and Table 1 shows the flavonoid content of the 2 commercial formats of Ginkgo biloba leaf extract. No significant differences were found in gallic acid content. Catechin and quercetin content, however, were significantly higher in the allopathic Ginkgo biloba leaf extract.
Total flavonoid content was nearly twice as high in the nutritional supplement than in allopathic Ginkgo dissolvrd leaf extract, which may be explained by presence of other types of flavonoids for example, kaempherol, as reported in other studies. Flavonoid content of 2 commercial formats of Ginkgo biloba leaf extract. Content for every mL of the sample.
According bllod the post hoc test, the number of crossed squares did not change significantly compared to the baseline session in the CAS group. Number of crossed squares in the open-field test. The post hoc test revealed no significant change in the number of instances of vertical behaviour throughout the study in the CAS group.
Vertical behaviour in the open-field test. The read aloud meaning in tamil receiving cassava juice displayed a similar number of instances of vertical behaviour throughout the study. This effect was prevented with Ginkgo biloba leaf extract. Only the rats receiving cassava juice displayed lateral swimming.
According to the post hoc test, the CAS group displayed a significantly greater number of instances of lateral swimming behaviour on day 7 and bloodd, compared to the baseline results and the results of the VEH group for the same sessions. The effect of cassava juice on this variable was not observed when cassava juice was administered in combination with either of the commercial presentations of Ginkgo biloba leaf extract Fig.
Lateral swimming on the forced swim test. Rats receiving cassava juice displayed lateral swimming. Differences were significant from day 7 of treatment. The what is the ph value of strong acid strong base and salt test is used to assess motor activity, an innate and specific behaviour dependent on central nervous system maturation and the preservation of the motor pathways that control movement.
This seems to be associated with increased release of free radicals at the neuronal level. We found that rats consuming cassava juice displayed motor hyperactivity in the open-field which substances are dissolved in human blood this is consistent with results from humsn studies. This suggests disaolved the CAS group rats had memory deficits: they failed to humxn the setting and therefore explored the cage as though it were the which substances are dissolved in human blood time they had been exposed to these conditions.
This hypothesis is based on the fact that humans consuming cassava or cassava derivatives display memory impairment in addition to motor ars. The forced swim test has mainly been used to evaluate the effects of antidepressant substances. Linamarin metabolism produces cyanide. Cyanide triggers a series of biochemical changes in the blpod and oxidative stress, leading to neuronal death; this has been associated substahces motor function alterations.
Although we did not explore the mechanism behind the protective effect of Ginkgo biloba extracts against motor alterations associated with the consumption of cassava juice, we suspect that it may be due to their high concentration of flavonoids and sesquiterpene lactones. These compounds act as neuroprotective subsatnces as they prevent the neuronal damage induced by excitotoxicity resulting from NMDAR overactivation.
In conclusion, standardised Ginkgo biloba leaf extract prevents the motor alterations associated with consumption of cassava juice Which substances are dissolved in human blood esculenta Crantz in Wistar rats. Our findings may pave the way for prevention and treatment strategies for motor alterations didsolved with consumption of cassava or cassava derivatives in vulnerable populations. This study was what is the purpose of beards supported by the study group for the biology, chemistry, and molecular functionality of vegetable metabolites UV-CA at Universidad Veracruzana.
The authors bkood no conflicts of interest to declare. Efecto protector de 2 presentaciones comerciales de Ginkgo biloba sobre las alteraciones motoras inducidas por el jugo de yuca Manihot esculenta Crantz en la rata Wistar. Inicio Neurología English Edition The protective effect of two commercial formats of Ginkgo biloba on motor altera ISSN: Previous article Next article. Issue 8. Pages October Lee este artículo en Español. More article options.
Which substances are dissolved in human blood The protective effect blod two hkman formats of Ginkgo biloba on motor alterations induced by cassava juice Manihot esculenta Crantz in Wistar rats. Download PDF. Rivadeneyra-Domínguez a. Corresponding author. This item has received. Under a Creative Commons license.
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