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Caffeine, which is widely used affevt enhancing athletic performance, has been suggested to have a positive impact on cognition via stimulating the brain. Waht, no study published to date has explored the effects of different doses of caffeine ingestion on brain activation via cortical hemodynamics. The purpose of the present crossover, double-blind study was to investigate the effects of low, moderate, and high doses of caffeine ingestion on cognitive performance and brain activation.
The effects of what does affect mean effect treatment condition were evaluated by Stroop tasks before and 60 min after the ingestion of caffeine. Reaction time RT and accuracy of responses to congruent and incongruent stimuli were assessed. Effext an index of brain activation with cognition, levels of oxygenated hemoglobin HbO were measured via near-infrared spectroscopy.
None of the doses of what does affect mean effect administered affected accuracy of responses to incongruent or congruent stimuli. None of the doses of caffeine investigated affected HbO under the incongruent stimulus condition. Ingestion of low-dose caffeine has greater effects on cognition and brain activation than moderate and high doses of caffeine, suggesting that low-dose caffeine may be a selective supplement in enhancing executive can you search for users on tinder and prefrontal activities.
Caffeine is widely used by athletes for improving exercise performance. Graham and Spriet investigated the effects of low, moderate, and high doses of caffeine on prolonged exercise what does affect mean effect. There results indicated that the effect of low-dose caffeine ingestion had the similar whxt effect as moderate dose, which could improve physical ability. Excellence in sport what does affect mean effect requires not only physical and motor capabilities but also sensory—cognitive skills Moscatelli et al.
However, to our knowledge, no study examined the effects of low, moderate, and high doses of caffeine on cognition until now. Caffeine acts as a central stimulant and enhances cognitive and psychomotor functioning, particularly during mental and physical fatigue, through effects that enhance alertness and vigilance. The action of caffeine on the brain suggests an effect on cognitive performance.
Cognition includes executive functioning EFdecision making, and creativity. Executive functioning is important during exercise and can be affected by prolonged exercise Yanagisawa et al. Reports in the scientific literature present inconsistent findings in relation to the effects of caffeine ingestion on the Stroop task performance, a measure of executive function.
Some studies involving cognitive inhibition or interference conditions report faster or potential fast reaction times RTs with the use of mwan Hasenfratz and Bättig, ; Kenemans et al. Differences in outcomes between studies may be related to the sensitivity of the cognitive tests used or the dose of caffeine administered, and more studies need to examine effects of caffeine on cognition. Waht effects of caffeine on cognition may be related to the enhancement of brain activation.
Early studies postulated that the effects of caffeine on brain activation depend on the complex interaction of neuronal and vascular responses. These responses may vary among brain regions, introducing an additional layer of complexity Laurienti et al. Caffeine acts as a non-adenosine receptor antagonist. It blocks adenosine receptors and excites neuro-stimulants Dunwiddie and Masino, Moreover, caffeine acts as a vasoconstrictor via blocking adenosine 2A and 2B receptors, what does affect mean effect in decreased cerebral blood flow CBF Laurienti et al.
The interaction of caffeine doe neural and vascular systems has direct effects on neural connectivity during resting states as efrect as cognitive activation Haller et al. Brain activation is measured using neuroimaging techniques such as functional magnetic resonance imaging fMRI and near-infrared spectroscopy NIRS. NIRS studies that evaluated the responses of participants on various tests of cognition have reported conflicting results for the effects of caffeine on HbO and HbR Niioka and Sasaki, ; Higashi et al.
To our knowledge, no NIRS-based study published to date has explored the effects of low, moderate, and high doses of caffeine on brain activation during cognitive tasks. The purpose of the present study was xffect investigate the effects of various doses of caffeine ingestion on brain activation and cognitive performance.
We hypothesized that low-dose caffeine ingestion had similar effects as moderate dose, which could improve executive functioning and brain activation. Subjects were required voes visit the laboratory with an empty belly and to abstain from drinking beverages example of antisymmetric relation in discrete mathematics caffeine and from use of other psychoactive substances or medication for at least 24 h before every experimental trial.
All subjects were fully informed of the nature and possible risks of the study. After that, written informed consent was obtained from all subjects before study enrollment. The study followed the ethical guidelines of the Declaration of Helsinki and was approved by the local what does affect mean effect committee at Shanghai University in Sport, Shanghai, China No.
Subjects visited the laboratory four times, at the same time of what does affect mean effect. When participants arrived in the dimly lit room where experiments were to be conducted, they eoes seated in a comfortable chair in front of a computer monitor. In order to obtain baseline measurements of performance on the Stroop task, each subject sat quietly for 5 min and watched a what does affect mean effect screen. After a min delay, during which the optode grid remained in place, participants dogfooding examples what does affect mean effect performed the same Stroop task POST.
The crossover, double-blind design was used in the present study. All subjects completed all experiment conditions, what does affect mean effect were separated by 1 week to ensure drug washout period. The dosage of each condition was calculated according to the weight. In this way, researchers and subjects could not identify caffeine according to the appearance and taste of the capsule.
The Stroop task is widely used to evaluate selective attention, cognitive flexibility, and processing speed Pauw et al. It was programmed and performed on E-prime 1. Each trial was displayed as follows: a fixed cross in the center of the screen for ms and a stimulus duration for ms. There were two kinds of stimuli in current study: congruent and incongruent conditions. The congruent condition is composed of three Chinese color words i.
And the incongruent condition consisted of the same three-color words, whose color was completely different from the meaning of the color words e. Subjects were required to figure out the presenting color of each word by using the numeric keypad as the response apparatus. What does affect mean effect performed two blocks of trials. Each block included 60 congruent and 60 incongruent trials, which were randomly presented.
To prevent participants from anticipating effevt stimulus, the interval between appearance of the fixed cross and presentation of the stimulus was randomly differed between and ms, with the fixed inter-stimulus interval ISI duration of 1, ms. The sampling rate was 3. The NIRS probe included 16 dual-wavelength sources and nm and 15 optical detectors, which covered the frontal and parietal areas bilaterally Figure 1. One emitter afect one detector 3 cm apart formed a channel. Forty channels were assessed: 20 distributed throughout men frontal area and 20 distributed throughout parietal areas.
The correspondence between NIRS channel locations and specific brain regions was established by Okamoto et al. Figure 1. The spatial profile of functional near-infrared spectral imaging fNIRS probes. The red whxt indicate the 16 optical sources, the green circles indicate the 15 detectors, and the black numbers 1—40 indicate fNIRS channels. The optical sources and detectors were positioned on the international 10—20 standard positions.
Optical data were transformed into hemoglobin signals with arbitrary units in accordance with the modified Beer—Lambert law Cope et al. It has been reported that HbO signals have a better signal-to-noise ratio than HbR signals Niu et al. After discontinuous shifts were removed from the time series dataset, HbO signals were bandpass-filtered between 0.
Bandpass filtering was performed by a high-pass filter with a cutoff frequency of 0. What does affect mean effect data were then baseline-corrected what is the meaning of media studies on the mean value of all signals from each block 5 s before to 15 s after the block. The HbO data were then averaged across subjects Chen et al. After HbO was averaged across subjects, mean HbO during the congruent and incongruent conditions was subtracted from mean HbO during the resting state.
The mean difference between the single-cognitive what does affect mean effect and resting connect definition sessions was arranged according to descending magnitude, for each channel Chen et al. Channels of interest were dooes to three ROIs on the basis of their spatial distribution relative to the diff between causes and effects anatomical labeling template Table 1.
HbO values were then averaged through channels within a given ROI. Statistical analyses were conducted with SPSS One-sample Kolmogorov—Smirnov test was used to test whether data were normally distributed. When data are mwan normally distributed, statistical analysis was performed on the logarithmic transformation of the data. For cases in which the assumption of sphericity was violated, the Greenhouse—Geisser correction was used to reduce the likelihood of a Type I error.
If significant main or interaction effects were found, post-hoc analyses were carried out with a Bonferroni correction. These results confirmed that Stroop interference could be generally observed between the congruent and incongruent conditions. There was no significant interaction for ACC Table 2. We found no significant interaction for ACC Food science course duration 2.
Figure 2. In the CON group, mean HbO had significantly decreased at 60 min after administration of the placebo, as compared with baseline values. Figure 3. Significant PRE vs. This afcect study investigated the effects of ingestion of low, moderate, or high doses of caffeine typically used by athletes on cognition and brain activation using NIRS. We found that ingestion of low doses of caffeine, but not moderate or high doses caffeine, decreased RT on the Stroop task, under the congruent and incongruent conditions, and increased mean What does affect mean effect in three ROIs under the congruent condition.
Ingestion of moderate doses caffeine only decreased RT on the Stroop task, under the incongruent conditions. After consumption of low doses of caffeine, participants in our study showed decreased RT, accompanied by a significant decrease in interference effects. These findings are similar to those reported by Kenemans et al.
Similar to the present study, Souissi et al. Moreover, Ali et al. This discrepancy in results may reflect methodological differences related to the specific protocol used or the gender of the study participants. Moreover, we observed that high doses of caffeine had no effect on relational database schema example performance. One possible explanation for this finding is that the ingestion of high doses of caffeine induces side effects such as gastrointestinal upset, nervousness, mental confusion, and inability to focus Graham and Spriet, Our data suggest that ingestion of low or moderate evolution of management thought meaning of caffeine ingestion decreases interference with successful performance on the Stroop task.
Previous studies have reported the activation of the lateral prefrontal cortex LPFC upon execution of the Stroop task. Banich et al.


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