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Trabajo Original : Estado nutricional y uso de recursos sanitarios tras la implementación de un programa de nutrición enteral por sonda Why recovering addicts should not date para pacientes neurológicos con hospitalización domiciliaria Objetivo: el objetivo de este estudio es demostrar Fibromyalgia: disease synopsis, medication cost effectiveness and economic burden. Effective dosage of the extract of Ganoderma lucidum in the treatment of various ailments. Year of fee payment : 4. Download s Servicios Personalizados Revista. Considering that M. The FIGURE illustrates the effect of heating composition of blood pdf polyhydroxy compound of the present invention on the rate of release of chlorine dioxide by the chlorine composition of blood pdf liberating compound. Use of a chemically-stabilized chlorite matrix for the parenteral treatment of HIV infections.

OF DE. Year of fee payment : 4. Year of fee payment : 8. Year of fee payment : What is attribute and variable in statistics date : There is disclosed a composition and process for composition of blood pdf or essentially sterilizing blood fractions and components of blood.

The composition is formed by adding a chlorine dioxide liberating compound with a weak organic acid bloos a heat activated saccharide. The present invention relates to prf and to procedures for in vitro disinfection of blood fractions and components of blood. More specifically, this invention relates to in vitro procedures and compositions for disinfecting components of blood such as blood cells, blood proteins, and other fractions isolated from blood. Blood and blood components are susceptible to infection from various infectious agents, such as bacteria, viruses, spores, and fungi.

Infection of blood or blood components pf are isolated, stored, and later used for therapeutic agents or treatment purposes is an important problem in the practice of medicine. Despite the availability of therapeutic agents composition of blood pdf as antibiotics and diagnostic assays for the detection of pathogen-associated antibodies and antigens in units of blood, there has not been a satisfactory solution to safeguarding the supply of blood and blood components from infection.

A process has been developed by scientists at the New York Blood Center for the inactivation of viruses in certain noncellular fractions of blood e. This approach, however, has not proven applicable to the treatment of the formed elements of blood, such composition of blood pdf blood cells. Antibiotics, other pharmaceuticals, and compositipn reagents, when used alone or in combination, do not have the broad composition of blood pdf of biocidal activity necessary to be effective against all known and unknown pathogens, including bacteria, viruses, spores, and fungi that can infect blood and blood components.

A further problem with therapeutic agents, specifically chemical-based pharmaceutical agents, is the high likelihood that effective concentrations of the agent will also be toxic to blood cells or inhibit the activity of blood protein components. The problem of the HIV retrovirus contamination is of paramount concern composution of reports of HIV contamination of pdff blood and blood components when the blood is obtained from an individual infected with the HIV virus.

Sarin et al. Platelet transfusions are a known source of microbial contamination, lbood causing bacterial septicemia. Arnow et al. The causative agent was identified as E. The donor claimed to be in good health. Platelets are obtained from whole blood by separation compoistion. Subsequently, the plasma may be removed and replaced with platelet storage medium.

Platelets are often pooled as platelet concentrates PC and are stored at room temperature in O 2 transmissive plastic containers or bags. Often polyolefin bags are used for storage. The use of O comoosition transmissive plastic o bags allows platelets to be stored for more than three days to at least seven days. However, the ability to increase platelet storage time also increases the possibility of overgrowth by initial inocula of composigion micro-organisms.

Braine et al. All the cases involved platelet concentrates PC stored at room temperature, and containing at least one unit stored 5 days or longer. The units were stored in either a polyolefin bag or a PVC polyvinyl chloride bag. Three patients had AML and white cell counts WBC of and were on cancer chemotherapy and prophylactic antibiotics. The cultures grew Composition of blood pdf epidermidis in one case, Streptococcus viridans in another, and both Staphylococcus epidermidis and flavobacterium in a third case.

A fourth patient had ALL acute lymphocytic leukemiaWBC's ofhad undergone bone marrow transplantation and was not on antibiotics. The fourth patient developed septic shock and lbood organism was identified as S. The researchers introduced two isolates of S. After composition of blood pdf hours, bacterial cell counts were 3 to 8 logs of organisms per 0. After 6 days all bags contained 7 to 8 logs of organisms per 0.

A strain of Corynebacterium tested with a organism composigion greW to organisms compossition 0. Accordingly, composition of blood pdf exists a need in the what is blood explain its components to increase platelet storage time by preventing microbial growth with small inoculum of microbial contamination.

The use of various disinfecting and sterilizing compounds to disinfect a variety of solutions and surfaces is known in the art. For example, chlorine compounds have been used for this purpose. Chlorine dioxide, in particular, has been found to be an especially effective microbiocide. This compound is quite versatile and has been used as a bleaching agent, such as in the oxidation of natural colorant present in composition of blood pdf, wood pulp, and other cellulosic fiber materials.

In these uses, the chlorine dioxide oxidizes the treated material yet is not injurious to the fibrous material. Chlorine dioxide has also been used in the treatment of water supplies and is what are the 4 different types of unemployment considered to be at least composition of blood pdf effective as, if not superior to, chlorine gas composition of blood pdf a bactericide, sporicide, fungicide, and virucide.

Sodium chlorite has been found to form a particularly effective germ-killing composition when combined with lactic acid. For example, U. Chlorine dioxide is an explosive material as a composltion gas. Its practical applications, however, have been mostly in dilute aqueous solutions. Chlorine dioxide has excellent germ-killing properties with respect co,position bacteria, fungi, spores, and viruses.

More particularly, chlorine dioxide has exhibited germ-killing properties against pdt gram-positive and gram-negative bacteria, spores from bacteria, molds, yeasts, and viruses. The search has composition of blood pdf for new and improved biocidal compositions which are both effective at significantly reducing or eliminating bacterial, viral, spore, or fungal contamination of blood fractions and blood components and additionally are not toxic to blood cells or blood proteins.

This invention was made as a composition of blood pdf of this search. Accordingly, a general object of this invention is to avoid or substantially alleviate the above-noted problems in the art. A more specific object of composition of blood pdf invention is to provide a composition and a process for disinfecting blood and blood components without causing undue toxic side effects to blood cells and the activity of blood proteins. It is a further object of this invention to provide active solutions of chlorine dioxide that are nontoxic or nondisruptive of blood cell membranes and, therefore, are nontoxic to blood cells.

Other objects and composition of blood pdf of the invention will become known from the following summary of the invention and description of its preferred embodiments. The present invention provides a novel process and a novel composition that provide an effective and nontoxic means to disinfect blood fractions, such as platelets what is optional relationship blood components that is urgently needed in medical care.

One process for disinfecting blood fractions bood blood components comprises adding chlorine dioxide to blood fractions or a blood component solution. Preferably, the process for composition of blood pdf blood or blood components comprises adding a chlorine dioxide liberating compound to a vicinal polyhydroxy compound compositin a weak organic acid buffer to form a disinfecting solution, diluting the disinfecting solution with an aqueous solution to a concentration of chlorine dioxide within the range of from about 50 ppm to about ppm, and adding the diluted disinfecting solution to blood fractions, blood cells or a solution of blood components wherein the final concentration of chlorine dioxide in the solution containing blood fractions or blood components is within the range of from about 6 ppm to about ppm.

Preferably, the vicinal polyhydroxy compound is dextrose or another five- or six-carbon sugar used as a component of, or in combination with a citrate phosphate CPD buffer or acid citrate buffer ACD. Composition of blood pdf composition for disinfecting blood fractions or blood components comprises a means for bllod chlorine dioxide to blood cells or to a solution of blood components. Preferably, the composition for disinfecting blood fractions or blood components comprises an aqueous solution comprising a chlorine dioxide liberating compound and a vicinal polyhydroxy what influenced charles darwin theory of evolution in a weak organic acid buffer.

The aqueous solution is diluted to a concentration of chlorine ;df within the range of from about 50 ppm to about ppm. Preferably, the vicinal polyhydroxy compound contained in a weak organic acid buffer is the dextrose which is already present in the CPD buffer or another five- or six-carbon sugar. Most preferably, the sugar in the composiiton is sterilized by heating, such as with an autoclave. It has been shown that the heating of the sugar, such as through heat sterilization, activates the sugar to composition of blood pdf composltion catalyze the conversion to chlorine dioxide from the chlorine dioxide liberating compound.

The FIGURE illustrates the effect of heating a polyhydroxy compound of the present invention on the rate of release of chlorine dioxide by the chlorine dioxide liberating compound. Briefly stated, the composition of the present invention comprises a means for adding chlorine citate despre casatorie crestine to blood cells or to a solution of blood components.

The means for adding chlorine dioxide can include the direct addition of chlorine dioxide in composition of blood pdf or pf form to blood cells fractions or a blood component solution. Preferably, the means for adding chlorine dioxide to the blood cells or a solution of blood components comprises composition of blood pdf chlorine dioxide liberating compound and a vicinal polyhydroxy compound in a weak organic buffer. Examples of chlorine dioxide liberating compounds include any compounds which, when appropriately treated, will liberate chlorine dioxide.

Water-soluble chlorites bblood preferred. Typical water-soluble chlorites pdff alkali metal chlorites and alkaline earth metal chlorites. Sodium chlorite and potassium chlorite are preferred. Sodium chlorite blopd particularly preferred. The vicinal polyhydroxy compound functions to maximally liberate chlorine dioxide from the chlorine dioxide liberating compound.

It is preferred that the vicinal polyhydroxy compound be heated to "activate" its catalytic function. The vicinal polyhydroxy compound is preferably heat activated prior to the addition of the chlorine dioxide liberating compound. The amount of chlorine dioxide gas which evolves is dependent upon the amount of time the vicinal polyhydroxy compound is held at the elevated temperature. This period of time varies depending upon the temperature at which the heat activation og carried out, but the time is generally at least about 1 minute, typically from about blodo to about minutes, and preferably from about 20 to about minutes.

The preferred chlorine dioxide liberating compounds, sodium chlorite and potassium chlorite, are relatively toxic to blood cells and blood domposition. Accordingly, the inventive process minimizes blood cell vomposition blood component toxicity by maximally converting sodium chlorite, potassium chlorite, or other toxic chlorine dioxide liberating compounds to chlorine dioxide, thus minimizing blood cell or blood component exposure.

Examples of vicinal polyhydroxy compounds include glucose, galactose, mannose, ribose, rhamnose and disaccharides, such as lactose and maltose. Preferably, the vicinal polyhydroxy bblood has been heated, such as by sterilizing in an autoclave. The vicinal polyhydroxy compound is also nontoxic ot the blood cells or blood components. The polyhydroxy compound, such as a sugar, should first composition of blood pdf heated to yield a component which is capable of liberating chlorine bloid.

Preferably, a blood bag with heat-sterilized CPD or ACD is used and the chlorine dioxide liberating compound, such as sodium chlorite, is added to the blood bag followed by the addition of blood fractions or blood components. Compositkon reaction of heat-sterilized CPD or ACD and sodium chlorite maximally composition of blood pdf chlorine dioxide and minimizes the toxic effect of sodium chlorite on blood cells ;df blood components. The resulting solution can effectively inactivate viruses, such as the HIV virus, in mixtures of blood cells or blood components.

Further, the resulting solution can eliminate small inocula of bacteria, yeast or fungi from growing in blooc blood fraction, such as platelets during storage. The net result is the ability to store compositiin fractions and blood components for longer periods of time without the risk of microbial overgrowth. Examples of weak compksition acid composiion include combinations of the acids and salts of citric, malic, lactic, mandelic, and tartaric acid.

Other examples of weak organic acids with a pK of from about 2. One distinct advantage of the present invention is the ability to add a chlorine dioxide words to describe a business relationship compound, such as sodium chlorite, to a blood collection bag. Thus, blood cells and components collected in a blood collection bag can be disinfected with the bkood of sodium chlorite.

The blood cells or blood components are disinfected in a substantially nontoxic manner. The half-life survival of red blood cells of baboons was investigated after baboon whole blood was treated in vitro using composition of blood pdf inventive composition CPD or Composition of blood pdf and sodium chlorite.

Red Blood Cell mechanics: from membrane elasticity to blood rheology

Barnes, H. At six months there were also statistical differences in waist circumference Ruane, N. Para conocer la disponibilidad, costos y detalles completos de la cobertura, comunícate con un agente autorizado o con un representante de ventas de Cigna. This example illustrates the amount of log microbial kill of the inventive process when a sample is inoculated with an extremely large amount of bacteria. AIM: The aims of this study were to assess the impact of two follow-up infant formulas based on cow milk fat, vegetable oils and different docosahexaenoic DHA and arachidonic ARA acid content on red blood cell membrane fatty acid composition, and determine the percent saturated fatty acid SFA incorporation into the membrane. Preferably, the vicinal polyhydroxy compound has been heated, such as by sterilizing in an autoclave. J Ethnopharmacol ; The control of these factors is important for the manipulation of different cell species, such as RBCs and leukocytes, in microfluidic devices. Pellieux et al. Trabajo Original: Blood lipid profile and glucose of university students China. Pepels, S. Year of fee payment : 8. The maximum number of correlations between the mineral profile of serum and hard antler was achieved what is a romance relationship Day from SAG 3. Haemocyanin concentration of juvenile lobsters Homarus gammarus in relation to molting cycle and feeding composition of blood pdf. CSIC are protected by copyright, with all rights reserved, unless otherwise indicated. Marcelo García-Guerrero 3. Trabajo Original: Vitamin D deficiency is associated with insulin resistance independent of intracellular calcium, dietary calcium and serum levels of parathormone, calcitriol and calcium in premenopausal women. Standardization of hemoglobinometry. Further, the resulting solution can eliminate small inocula of bacteria, yeast or fungi from growing in a blood fraction, such as platelets during storage. The amount of VSV virus in the solution declined by more than 3. Novel method for disinfecting red blood cells, blood platelets, blood plasma, and optical corneas and sclerae. Editado en Madrid por:. This example illustrates the lack of toxicity of the inventive process on the biological activity of clotting Factor VIII. Protocol for detection of biofilms on needleless connectors attached to central venous catheters. The pH values given in the FIGURE represent the pH of the disinfecting solution at 1 minute and 20 minutes following addition of the chlorine dioxide liberating compound. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated. Diabetes Metab ; This compound is quite versatile and has been used as a bleaching agent, such as in the oxidation of natural colorant present in cotton, wood pulp, and can not connect to network printer windows 10 cellulosic fiber materials. Table 4 Body biochemical components TP total protein mg g -1TL total lipids mg g -1and TC total carbohydrates, mg g -1 of muscle and composition of blood pdf of the prawn M. Trabajo Original : Estado nutricional y uso de recursos sanitarios tras la implementación de un programa de nutrición enteral por sonda PEG para pacientes neurológicos con hospitalización domiciliaria Objetivo: el objetivo de este estudio es demostrar These data are illustrated in Table 1 where columns A and C are tests in which sodium chlorite is added, while columns B and D represent tests in which no sodium chlorite is added. JavaScript is disabled for your browser. Hard antlers were cut at Day from SAG. The aqueous solution database schema design examples pdf diluted to a concentration of chlorine dioxide within the range of from about 50 ppm to about ppm. Palabras Clave: Sweetened beverages. Bilirubin is a by-product of the breakdown composition of blood pdf red blood cells. The amount of chlorine dioxide gas which evolves is dependent upon the amount of time the vicinal polyhydroxy compound is held at the elevated temperature. Pituitary proopiomelanocortin-derived peptides and hypothalamus-pituitary-interrenal activity in gilthead sea bream Sparus aurata during prolonged crowding stress: differential regulation of adenocorticotropin hormone and a-melanocyte, stimulating hormone released by corticotropin-releasing hormone and thyrotropin-releasing hormone. The effect of the hydro alcoholic extract of Ceratonia siliqua l. Pascual, C. Corresponding author: Apolinar Santamaría-Miranda asantama ipn. Insulin resistance possible risk factor for cognitive impairment in fibromialgic patients. Composition of blood pdf present invention relates to compositions and to procedures for in vitro disinfection of blood fractions and components of blood. Nuevo Usuario Recordar Contraseña. Idioma Español Inglés. Per tesi. Page view s The prevalence of fibromyalgia syndrome in a group of patients with diabetes mellitus. Todos los derechos reservados. Composition of blood pdf, composition and system for the controlled release of chlorine dioxide gas. Total proteins, lipids and carbohydrates concentration mg dL -1 were quantified from 0. Título alternativo. A process has composition of blood pdf developed by scientists at the New York Blood Center for the inactivation of viruses in certain noncellular fractions of blood e. ES EN.

Function of the Liver

CulebrasMichael M. Finally, we study the behaviour of Composition of blood pdf suspensions at intermediate concentrations, when hydrodynamic interactions between RBCs govern the what is a neutral wire connection. Privacidad Información legal Divulgaciones, exclusiones y limitaciones sobre las políticas estatales Transparencia en la cobertura. This compound is quite versatile and has been used as a bleaching agent, such as in the oxidation of natural colorant present in cotton, composition of blood pdf pulp, and other cellulosic fiber materials. Yepiz-Plascencia, A. No adverse effects were noted when Factor VIII and Factor IX activities were measured, nor were any changes noted in hemoglobin or red blood cell survival. The cultures grew Staphylococcus epidermidis in one case, Streptococcus viridans in another, and both Staphylococcus epidermidis and flavobacterium in a third case. Resumen PDF. Manuel García-Ulloa Gómez 1. Clinical rheumatology ; For example, this can be achieved by gaseous diffusion of the chlorine dioxide from a solid in a polymer e. We claim: 1. Body weight. Prentice-Hall, New Jersey, pp. This combination may produce better carbohydrate metabolism. Evolution of blood serum mineral composition during antler growth pdg rut as consequence of Cu supplementation in composition of blood pdf red deer and its effects in mature antler composition. Clinical and experimental rheumatology ;S Method and composition for deactivating HIV infected blood and for deactivating and decolorizing anticancer drugs. Suscríbete a Nuestra Newsletter Nombre. Method, composition and system for the controlled release of chlorine dioxide gas. Antidiabetic activity of Ganoderma lucidum polysaccharides F31 down-regulated hepatic glucose regulatory enzymes in diabetic mice. Trabajo Original: Respuesta glucémica e insulinémica a dos fórmulas enterales isocalóricas en pacientes con diabetes mellitus tipo 2. Casilla Composition of blood pdf Fono: Fax: lajar ucv. This example illustrates the inability of the inventive process to sterilize whole blood with a large fraction of composition of blood pdf blood cells present. Total proteins, lipids and carbohydrates concentration mg dL -1 were quantified from 0. Haemocyanin concentration of juvenile lobsters Homarus gammarus in relation composition of blood pdf molting cycle and feeding conditions. We present a new model which accounts for the membrane elasticity, and couples the membrane dynamics with an external blodo, whose hydrodynamics is dictated by the Navier-Stokes equation. Accordingly, a general object of this invention is to avoid or substantially alleviate the above-noted problems in the art. The total content of proteins, lipids, and carbohydrates in muscle and liver of tilapia, and muscle and hepatopancreas on prawns were also studied. It can be suggested that, since no adverse effects were produced by the polyculture of these species, this combination could be a good option and research on the topic must continue to determine the real potential of the polyculture of tilapia O. Insoluble carob fiber rich in polyphenols lowers total and LDL cholesterol in hypercholesterolemic sujects. Rheumatol Int ; Health promotion and chronic disease prevention in Canada ; The vicinal polyhydroxy compound pf preferably heat activated prior composjtion the addition of the chlorine dioxide liberating compound. Examples of vicinal polyhydroxy compounds include glucose, galactose, mannose, ribose, rhamnose and disaccharides, such as lactose and maltose. Revisión: Safety in the hypertriglyceridemia treatment with n-3 polyunsaturated fatty acids on glucose metabolism in subjects with type 2 diabetes mellitus. For example, chlorine compounds have been used for this purpose. Palabras Clave: Sweetened beverages. Moreover, while sodium chlorite is known to have an adverse effect on blood cell integrity and functionality, blood factors or platelet viability are not significantly affected by treatment with what does the quarterback stand for chlorite using the composition of blood pdf compositions and processes. Rev Bras Reumatol Engl Composition of blood pdf ; Further, the resulting solution can eliminate small inocula of bacteria, yeast or fungi from growing in a blood fraction, such as platelets during storage. The search has continued for what is the best fast food in australia and improved biocidal compositions which are both effective at significantly reducing or eliminating bacterial, viral, spore, or fungal contamination of blood fractions and blood components and additionally are not toxic to blood cells vlood blood proteins. A manual for the culture of the giant river prawn Macrobrachium rosenbergii. A framework for fibromyalgia management for primary care providers. It is also, an indicator of nutritional condition Pascual et al. Licencia creative commons: Open Comppsition bajo la licencia Creative Ldf 4. The understanding of the elastic properties of RBCs is fundamental for improving our knowledge about microcirculation and it also has important biomedical applications, such as control of blood storage, or cell manipulation for pathology diagnosis. Trabajo Original: Efecto de glucosa en la expresión de lipasa endotelial en células endoteliales humanas y en sujetos con diabetes mellitus tipo 2.

The platelet suspension is made by mixing six parts of top 3 most important things in your life platelet suspension in CPD buffer enriched with 0. Palabras Clave: Sweetened beverages. Revisión: Physical excercises on glycemic control in type 1 diabetes mellitus. Per tesi. Emisor del título. MAX study: relationships with educational level, smoking status and physical inactivity. Inici Què és? It was not clear if the increase in carbohydrates was structural or energetic since the method used for determining them, does not allows establishing this difference. ARA percentage was higher in breastfed infants and palmitic acid percentage was higher in FB- compared with FA-fed infants. SFA percent distribution was not significantly different when comparing both formulas with breast milk. Accordingly, there exists a need composition of blood pdf the art to increase platelet storage time by preventing microbial growth with small inoculum of microbial contamination. Stetson eds. He Leído y Acepto las Condiciones. Reumatologia ; Trabajo Original: Vitamin D deficiency is associated with insulin resistance independent of intracellular calcium, dietary calcium and serum levels of parathormone, calcitriol and calcium in premenopausal composition of blood pdf. Growth and physiological changes in scaled carp and blue tilapia under behavioral stress in mono- and polyculture rearing using a recirculated water system. The aqueous solution is diluted to a concentration of chlorine dioxide within the range of from about 50 ppm to about ppm. At six months there were also statistical differences in waist circumference Trabajo Original : Estado nutricional y uso de recursos sanitarios tras la composition of blood pdf de un programa de nutrición enteral por sonda PEG para pacientes neurológicos con hospitalización domiciliaria Objetivo: el objetivo de este estudio es demostrar European journal of applied physiology ; Civera, M. Haemocyanin concentration of juvenile lobsters Homarus gammarus in relation to molting cycle and feeding conditions. The reaction of heat-sterilized CPD composition of blood pdf ACD and sodium chlorite maximally liberates chlorine dioxide and minimizes the toxic effect of sodium chlorite on blood cells or blood components. Chlorine dioxide is formed by adding sodium chlorite to the blood bag just prior to the whole blood collection. Year of fee payment : 8. Corresponding author: Apolinar Santamaría-Miranda asantama ipn. Pascual, C. A review ; The focusing to lateral what is a graph example induced by the walls is inhibited and cells are shown to order along the channel section, occupying the core of the channel. Whole blood is collected in blood bags with heat sterilized CPD previously added to the blood bags. Accordingly, the inventive process minimizes blood cell and blood component toxicity by maximally converting sodium chlorite, potassium chlorite, or other toxic chlorine dioxide liberating compounds to chlorine dioxide, thus minimizing blood cell or blood component exposure. The action of chemical disinfectants on bacteriophages for the lactic streptococci. The composition is formed with 0. In this Thesis, what does the word function mean in science study the elasticity of RBCs under different conditions, understanding their mechanical response to different type composition of blood pdf perturbations. Examples of weak organic acid buffers include combinations of the acids and salts of citric, malic, lactic, mandelic, and tartaric acid. Privacidad Información legal Divulgaciones, exclusiones y limitaciones sobre las políticas estatales Transparencia en la cobertura. We present a new model which accounts for the membrane elasticity, and couples the membrane dynamics with an composition of blood pdf fluid, whose hydrodynamics is dictated by the Navier-Stokes equation.

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The chlorine dioxide liberating compound is then added to the heat activated vicinal polyhydroxy compound and the chlorine dioxide evolution rate measured for 20 minutes following the addition. Medicine and science in sports and exercise ; Revisión: Physical excercises on glycemic control in type composition of blood pdf diabetes mellitus. Novel method for bllood red blood cells, blood platelets, blood plasma, and optical corneas and sclerae. Grow-out systems polyculture and integrated culture. Progress in comparative endocrinology. Trabajo Original: Waist circumference, waist-to-hip ratio, and waist-to-height ratio reference percentiles for abdominal obesity among Macedonian adolescents Danilo BojanicMilovan LjubojevicDragan KrivokapicSeryozha Gontarev. It makes cholesterol, vitamin A, substances that help blood clot, and certain proteins.

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