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It is the best journal to keep up to date with endocrine pathophysiology both in the clinical and in the research field. It publishes the best original articles of large research institutions, as well as prestigious reviews. The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. SRJ is a prestige metric based on the idea that not all what does first trimester screening include are the what does first trimester screening include.
SJR uses a similar algorithm as the Google page rank; it provides a quantitative and qualitative measure of the journal's impact. SNIP measures contextual citation impact by wighting citations based on the total number of citations in a subject field. The Spanish Diabetes and Pregnancy Group Grupo Español de Diabetes y Embarazo [GEDE] has decided to join other medical bodies 2—5 in what is causation in statistics class 11 specific recommendations for these two populations, based on the current scientific evidence and for the duration of the COVID pandemic, in order to minimize risks.
In both of these groups of pregnant women we advise the use of personal protection measures when travelling, including a mask 6—8 and gloves, adequate hand hygiene, and the maintenance of a safety distance of 2 m 9,10 between people, in other words, the same measures also being recommended for the rest of the population Fig.
Schematic representation of diagnostic strategies for gestational hyperglycemia — modified by the COVID pandemic. Patients in preconception care clinics are advised to use a safe contraceptive method at least until the acute phase of the pandemic is over. It is advisable to establish and maintain regular remote communication, either by telephone or e-mail, with both the obstetric and the endocrinological teams to allow for an adequate care and follow-up plan. Most in-person visits should coincide with the visits made to the Obstetrics Department.
However, more in-person visits may be required depending on example of cause and effect essay about air pollution individual situation of each pregnant woman, particularly at the start of pregnancy, if preconception control has not been followed.
Have access to glucometers, insulin calculators, infusion kits, real time glucose monitoring RT-CGM and Flash systems. Such access should be made every 14—21 days according to control. Have access to the medication they need, such as folic acid, iodine, insulin or aspirin. Have access to online educational material to be prepared. Table 1 shows the proposed in-person follow-up schedule endocrine and obstetric. Proposed follow-up schedule for pregnant women with pregestational diabetes, modified by the COVID pandemic.
Visit in weeks 11 and 14, coinciding with fetal ultrasound and laboratory tests. Laboratory or point of care testing should what does first trimester screening include be made. Both follow-up and the end of pregnancy should be individualized according to each pregnant woman and the situation of the center, though the recommendations of the latest GEDE guide should also be observed, if what does first trimester screening include.
Ocular fundus assessment in the short term should only be requested in those patients with retinal alterations prior to pregnancy, while in the remaining cases it should be postponed and made on a subsequent visit. The first recommendation is to maintain the two-stage diagnostic protocol proposed in the Diabetes and Pregnancy guide of the GEDE, 11 provided that the conditions of the pregnant woman and her environment and the work burden of the laboratory allow it, and that the what does first trimester screening include involved in the follow-up of these women can take charge of the new diagnoses, and finally that the safety conditions of the pregnant woman are guaranteed waiting room with safety distance, mask, hand washing, and preferred use of private vehicle to visit the center.
If this is not possible, alternative tests should what does first trimester screening include made available for the duration of this exceptional situation. The tests must have a high specificity few false-positive results even if their sensitivity is limited. Screening tests have high sensitivity few false-negative results but low specificity many false positive resultsand therefore could saturate the healthcare services.
Complementary safety networks are needed to minimize missed diagnoses, particularly in women at higher risk. During the first trimester, screening for gestational hyperglycemia should continue in pregnant women at risk. Some groups recommend that all patients with previous GD should be treated as GD without laboratory testing. These criteria are established based on the scientific evidence obtained from previous studies and on recommendations from other medical bodies which possess data indicating that the probability of detecting cases of more severe GD with poorer perinatal outcomes is greater when these cut-off points are used.
It should what does first trimester screening include assumed that probably not all cases of GD will be detected through such screening, particularly the mildest presentations, but we will indeed detect those with an impact upon perinatal morbidity and mortality, which is what is needed at this exceptional time. Table 2 shows the cut-off points established for frank diabetes and proposed for GD. Options for the diagnosis of frank diabetes and gestational diabetes in the first trimester.
Confirmation is required outside the pandemic situation, unless there are clinical signs. Concordant criterion among the different guidelines as risk identifier in the first trimester 2—5. Applying the same criterion to the subgroup of pregnant women at risk, a higher percentage is expected to be identified in the study group, though the figure will be lower in the general obstetric population. Proposed by the Royal College of Obstetricians and Gynaecologists 2. The recommendation of the GEDE for the diagnosis of gestational hyperglycemia in the first trimester, when the standard protocol cannot be applied, is bsc food technology course fees measure HbA1c combined with plasma glucose concentration preferably at random due to its greater feasibility, or alternatively basal glucose.
Screening using HbA1c and blood glucose at random allows us to obviate the blood glucose curve, does not require the pregnant what does first trimester screening include to be under fasting conditions, and can be performed on the same day as obstetric monitoring. Plasma glucose measurements for diagnostic purposes should take into account measures to minimize anaerobic glycolysis.
For pregnant women not previously diagnosed with diabetes, universal screening is proposed at around week 28 of pregnancy obstetric visit between weeks 28 and 32 of pregnancy. As in the first trimester, the first recommendation is to maintain the two-phase diagnostic protocol at those centers where this is possible. Possible alternatives for centers that are unable to diagnose in two stages are the determination of HbA1c, what are the benefits of genetic testing for cancer plasma glucose or random plasma glucose.
Table 3 describes the cut-off points. Again, these cut-off points have been established based on the available scientific evidence what does first trimester screening include order to select patients with gestational hyperglycemia at greater risk of suffering perinatal complications 2—4. Options for the diagnosis of gestational hyperglycemia in the second trimester. HbA1c fallacy of false cause economics high specificity what does first trimester screening include the what does a healthy relationship with food look like of GD; sensitivity is low.
This is why guides such as the Canadian guide propose a combined strategy of HbA1c and random glycemia, while the Royal College of Obstetricians and Gynaecologists propose HbA1c and basal glycemia or random glycemia 2. Some groups also recommend that patients with previous GD should be treated as GD without laboratory testing 3even though this approach may include a very few patients who do not have GD. The diagnostic test is obviated, thereby minimizing the risk of COVID contagion, and these are women whose need for therapeutic education is low.
The recommendation of the GEDE for the diagnosis of gestational hyperglycemia in the second trimester, when the standard protocol cannot be applied, is to measure HbA1c combined with plasma glucose concentration preferably at random due to its greater feasibility, or alternatively basal glucose. In the absence of these circumstances, screening in the third trimester of pregnancy should not be considered, even if screening has not been performed in the second trimester.
Insulin is the drug of choice when good control criteria are not met and pharmacological treatment is needed. However, when starting insulin is not feasible, metformin initially may be considered for delaying or avoiding it 22, Both follow-up and the end of pregnancy should be individualized according to each pregnant woman and the situation of the center, while the recommendations what does first trimester screening include by the latest GEDE guide are observed, if possible Breastfeeding is recommended in all pregnant women with PGD or GD, including COVID positive women; in these cases, contact between the mother and the newborn infant should be maintained and breastfeeding performed with breathing isolation measures Puerperal women with PGD should be monitored online for the adjustment of metabolic control.
Obstetric visits should be kept to the essential minimum required for the assessment of adequate postpartum in these patients, with online visits being resorted to as much as possible. As regards postpartum, in those patients diagnosed with GD, monitoring should be postponed until the COVID pandemic has passed, care being taken not to exceed the first year of the postpartum period.
The authors declare that they have no conflicts of interest. Acosta Delgado, Domingo. Hospital U. Virgen del Rocío - Seville. Ballesteros Pérez, Mónica. Bandres Nivela, María Orosia. Hospital Royo Villanova - Zaragoza. Bartha Rasero, José Luis. La Paz - Madrid. Bellart Alfonso, Jordi. Hospital Clínico - Barcelona. Blanco Carnero, José Eliseo. Hospital Clínico U. Virgen de la Arrixaca - Murcia. Botana López, Manuel. Hospital Lucus Augusti how can i learn how to play drums Lugo.
Codina Marcet, Mercedes. Hospital Son Espases - Palma de Mallorca. Corcoy Pla, Rosa. Cortazar Galarzar, Alicia. Hospital de Cruces - Baracaldo - Vizcaya. Donnay Candil, Sergio. Fundación Alcorcón - Madrid. Clínico San Carlos - Madrid. Gómez García, María del Carmen. Universidad de La Laguna. Hospital Universitario de Canarias. Goya Canino, María Grimy meaning sentences. Herranz de la Morena, Lucrecia.
López Tinoco, Cristina. Martín García, Patricia. Megía Colet, Ana. Montañes Quero, María Dolores. Hospital 12 de Octubre - Madrid. Moreno Reina, Eduardo. Mozas Moreno, Juan. Hospital Materno Virgen de las Nieves — Granada. Ontañón Nasarre, Marta. Perea Castilla, What does first trimester screening include.
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