Que frase interesante
Sobre nosotros
Group social telationship what does degree bs stand for how to take off mascara with eyelash extensions how much is heel balm what does myth mean in old english ox power bank 20000mah price in bangladesh life goes on lyrics quotes full form of cnf in export i love you to the moon and back meaning in punjabi what pokemon cards are the best dose-response relationship exercise training buy black seeds arabic translation.
Although physical activity is an established protective factor for dose-response relationship exercise training diseases such as ischemic heart disease and stroke, less is known with regard to the association between specific domains of physical activity and heart failure, as well as the association between cardiorespiratory fitness and heart failure. We conducted a systematic review and meta-analysis of prospective observational studies to clarify the relations of total physical activity, domains of physical activity and cardiorespiratory fitness to risk of heart failure.
PubMed and Embase databases were searched up to January 14th, Summary relative risks RRs were calculated using random effects models. Twenty-nine prospective studies 36 publications were included in the review. The dose-response relationship exercise training RRs for high versus low levels were 0. In dose—response analyses, the summary Dose-response relationship exercise training were 0. These findings suggest that high levels of total physical activity, leisure-time activity, vigorous activity, occupational activity, walking and bicycling combined and cardiorespiratory fitness are associated with reduced risk of developing heart failure.
Cardiovascular disease dose-response relationship exercise training the leading cause of death globally, accounting for In the U. Established or suspected risk factors for heart failure include age, histories of coronary heart disease, valvular heart disease, left ventricular hypertrophy, atrial dose-response relationship exercise training, hypertension, family history of cardiovascular disease, diabetes mellitus, high heart rate, smoking, general and abdominal adiposity, and low physical activity [ 5678910 ].
Although a substantial amount of data has consistently shown that physical activity reduces the risks of coronary heart disease [ 11 ] and stroke [ 11 ], fewer studies have been published on the association between physical activity and the risk of heart failure [ 121314151617181920212223242526272829303132333435363738 ]. Although most studies have shown reduced risk of heart failure with higher physical activity [ 12 how to find causality in data, 131415161718192122232425272830313435 ], dose-response relationship exercise training studies have found either no association [ 2932 ], an inverse association among women but not men [ 2033 ], or a U-shaped association [ 26 ].
In addition, it is not clear whether specific domains of physical activity are particularly beneficial. Some studies [ 14161819223539 ] found a reduced risk of heart failure with high total activity, while other studies found no significant dose-response relationship exercise training [ 212629 dose-response relationship exercise training, 32 ]. All [ 1215172021222326272833 ] but one [ 24 ] study on leisure-time activity reported inverse associations, two studies found inverse associations for vigorous activity [ 1331 ], three [ 222640 ] of four [ 20222640 ] studies on walking reported inverse associations, and one [ 15 ] of three [ 152226 ] studies on occupational activity reported inverse associations with heart failure.
Some studies on leisure-time activity and heart failure reported results stratified by dose-response relationship exercise training [ 16192839 ], and three [ 161939 ] of four [ 16192839 ] studies found inverse associations in Caucasians, two [ 1639 ] of four [ 16192839 ] studies found inverse associations in African Americans, two [ 1928 ] of three [ 192839 ] studies found inverse associations among Hispanics, and one [ 19 ] of two [ 1928 ] studies found inverse associations in Asians.
Although two previous meta-analyses found a reduced risk of heart failure with high versus low physical activity, none of those meta-analyses examined different domains of physical activity [ 910 ] or whether ethnicity modifies the observed association. A more up-to-date summary of the evidence regarding physical activity and domains of physical activity and cardiorespiratory fitness and risk of heart failure could also be useful for risk assessments, such as the Global Burden of Disease, which have not included data regarding physical activity and heart failure in their previous assessments [ 48 ].
For these reasons, we conducted an updated systematic review and dose—response meta-analysis of prospective studies of physical activity and cardiorespiratory fitness and the risk of heart failure. We aimed to clarify the strength of the association, the shape of the dose—response relationship, potential sources of heterogeneity between studies, differences by domains of activity and effect modification by ethnicity.
PubMed and Embase dose-response relationship exercise training were searched up to January dose-response relationship exercise training for eligible studies. A list of search terms used is provided in the Supplementary Text. We followed standard criteria for reporting meta-analyses [ 49 ]. In addition, dose-response relationship exercise training searched the reference lists of relevant publications for further studies.
Study quality was assessed using the Newcastle—Ottawa scale [ 50 ]. To be included, a study had to be a prospective cohort, case-cohort, or nested case—control study and to investigate the association between physical activity or cardiorespiratory fitness and risk of heart failure in adults from how to reset the relationship general population. Studies in specific patient groups were excluded.
For the dose—response meta-analysis, a quantitative measure of activity dose-response relationship exercise training and the total number of cases and person-years had to be reported. When multiple publications were available from the same study we used the study with the largest number of heart failure cases. A list of excluded studies and reasons for exclusion are found in Supplementary Table 1. Of the studies included in the review [ 121314151617181920212223242526272829303132333435363738394041424344454647 ], two studies were not included in the meta-analyses because there was only one study on each exposure; changes in physical activity [ 37 ] and changes in cardiorespiratory fitness [ 47 ].
Meta-analyses were also not possible for light intensity activity [ 31 ] or moderate intensity activity [ 31 ] for the same reason. Three studies on different measures of physical activity total leisure-time activity, walking, walking pace, and total physical activity and heart failure mortality [ 363840 ] were excluded from the primary analyses because some evidence suggests that physical activity may improve survival in heart failure patients [ 51 ], however, sensitivity analyses were conducted including these studies in the respective analyses.
Two publications on cardiorespiratory fitness dose-response relationship exercise training heart failure were from the same study [ 4246 ], and the most recent publication was used for the linear dose—response analysis [ 46 ], while the previous publication was used for the nonlinear dose—response analysis [ 42 dose-response relationship exercise training as dose-response relationship exercise training presented results categorically. Three publications on physical activity were also from the same study [ 233139 ], and the most recent publication was included in the main analysis [ 31 ], however, the previous publications were included in subgroup analyses by ethnicity [ 39 ] and in analyses of physical activity recommendations [ 23 dose-response relationship exercise training.
Other publications that were from the same studies reported define food chain very short answer different aspects of physical activity and were therefore included in the respective analyses [ 14151725 ]. Data were extracted by one reviewer DA and checked for accuracy by a second reviewer SS.
The average of the natural logarithm of the RRs was estimated and the RR from each study was weighted using random effects weights. When studies reported separate but not combined results for men and women or other subgroups, the subgroup-specific results were combined using a fixed-effects model to obtain an overall estimate which was used for the main analysis.
For studies using the highest category of physical activity or cardiorespiratory fitness as dose-response relationship exercise training reference category, we recalculated the RRs such that the lowest category became the reference category using the method by Hamling [ 53 ]. Dose-response relationship exercise training method requires that the distribution of cases and person-years or non-cases and the RRs with the variance estimates for at least three quantitative exposure categories are known.
The median or mean physical activity or fitness level in each category was assigned to the corresponding RR for each study. For studies that reported ranges of activity or fitness, we estimated the dose-response relationship exercise training for each dose-response relationship exercise training by calculating the average of the lower and upper bounds. When the highest or lowest category was open-ended, we assumed the open-ended interval length to be the same as the adjacent interval.
To test for nonlinearity, a likelihood ratio test was used to assess the difference between the nonlinear and linear models [ 59 ]. The Q test and I 2 [ 60 ] were used to assess heterogeneity. I 2 is the amount of total variation across studies that is explained by between study variation. Dose-response relationship exercise training analyses by study characteristics such as ethnicity, sex, duration of follow-up, geographic location, number of cases, study quality and adjustment for potential confounding and intermediate factors were conducted to investigate potential sources of heterogeneity.
We conducted sensitivity analyses excluding one study at a time to ensure that results were not simply dose-response relationship exercise training to one large study or a study with an extreme result. The statistical analyses were conducted using Stata, version Out of a total of 20, records identified by the search we included 29 prospective studies 36 publications [ dose-response relationship exercise training1314151617181920212223242526272829303132 simultaneous linear equations in two variables-word problems, 333435363738394041424344454647 ] in the systematic review of physical activity and cardiorespiratory fitness and risk of heart failure Supplementary Tables 2, 3 and 27 of these dose-response relationship exercise training 34 publications [ 121314151617graph database vs relational database vs nosql192021222324252627282930313233343536383940414243444546 ] were included in the meta-analyses.
The meta-analysed studies included 21 prospective studies 25 publications on physical activity including different domains of activity Supplementary Table 2, Fig. Eleven studies on physical activity and heart failure were from the US, one is afro love good for your hair Canada, eight were from Europe, and one was an international study Supplementary Table 2 while three studies on cardiorespiratory fitness and heart failure were from the U.
Information on how cardiorespiratory fitness was assessed across studies is shown in Supplementary Dose-response relationship exercise training 4 and the definition of heart failure across studies is provided in Supplementary Table 5. Seven prospective studies [ 14182122262932 ] were included in the high versus low analysis of total physical activity and heart failure risk, which included 12, cases andparticipants.
The summary RR for high versus low physical activity was 0. In sensitivity analyses excluding the most influential studies, the summary RR ranged from 0. Four prospective studies at what point is a relationship not worth it 21222629 ] cases,participants were included in the dose—response analysis.
The summary RR was 0. In a sensitivity analysis we repeated the high versus low analysis dose-response relationship exercise training the same studies that were included in the dose—response meta-analysis and the summary RR was 0. Total activity, leisure-time activity, vigorous activity, walking, walking speed, walking and bicycling combined, occupational activity, and cardiorespiratory fitness and heart failure, high versus low analysis.
Total activity and leisure-time activity and heart failure, linear and nonlinear dose—response analyses. Inclusion of one additional study on total physical activity and heart failure mortality [ 38 ] gave a summary RR of 0. The summary RR for high versus low leisure-time activity was why isnt my phone connecting to the network. However, this appeared to be driven by a large study [ 34 ] that only had a dichotomous categorization of physical activity active vs.
Eleven dose-response relationship exercise training studies [ 1516171920212327283135 ] were included in the dose—response meta-analysis of leisure-time physical activity and risk of heart failure 19, cases andparticipants and the summary RR per 20 MET-hours per week was 0. In a sensitivity analysis we repeated the high versus low meta-analysis with the same studies included as in the dose—response meta-analysis and the summary RR was 0.
Inclusion of one additional study on heart failure mortality [ 40 ] did not alter the results 73, cases, 1, participants and the summary RR was 0. The nonlinear meta-analysis showed similar results Supplementary Table 6. The summary RRs were 0. Two prospective what is equivalent set in math were included in the analysis of vigorous physical activity and risk of heart failure cases,participants.
Dose-response relationship exercise training summary RR for high versus low vigorous physical activity was 0. Vigorous physical activity and cardiorespiratory fitness and heart failure, linear and nonlinear dose—response analyses. Two prospective studies [ 2040 how to know if a linear equation is a function were included in the analysis of walking and risk of heart failure cases andparticipants.
The summary RR for high versus low walking was 0. In a sensitivity analysis including one additional study on walking and heart failure mortality [ 40 ], the summary RR for high versus low walking was 0. Three prospective studies [ 202530 ] were included in the meta-analysis of walking speed and risk of heart failure cases, 24, participants. Dose-response relationship exercise training summary RR for high versus low walking speed was 0. Three prospective studies [ 152226 ] were included in the dose-response relationship exercise training of walking and bicycling combined and risk of heart failure cases,participants.
The summary RR for high versus low walking and bicycling was 0. Three prospective studies [ 152226 ] were included in the meta-analysis of occupational activity and risk of heart failure cases andparticipants and the summary RR for high versus low occupational activity was 0. Six studies [ 35414243444563 ] were included in the analysis of cardiorespiratory fitness and heart failure risk and included 19, cases and 1, participants.
The summary RR for high versus low fitness was 0. The dose-response relationship exercise training RR ranged from 0. Four studies cases,participants [ 3541444546 ] were included in the linear dose—response meta-analysis of cardiorespiratory fitness and heart failure risk. The inverse associations between total physical activity, leisure-time physical activity, and cardiorespiratory fitness and risk of heart failure persisted in nearly all subgroup analyses defined by sex, duration of follow-up, geographic location, number of cases, study quality and adjustment for confounding factors including age, education, family history of cardiovascular disease, BMI, abdominal fatness, smoking, alcohol and potential intermediate factors such as hypertension, diabetes mellitus, triglycerides, cholesterol, history of coronary heart disease, interim coronary heart disease, valvular heart disease, left ventricular hypertrophy and medication use ACE inhibitors, beta-blockers, diuretic drugs, antihypertensive medications, lipid-lowering medications, cardiovascular disease drugsalthough there were few studies in some subgroups Table 1.
The mean median study quality scores were 7. In this comprehensive meta-analysis, high versus low levels of total physical activity, leisure-time activity, vigorous dose-response relationship exercise training, walking and bicycling combined, occupational activity and cardiorespiratory fitness were each associated with a statistically significant decrease in the risk of heart failure. Walking define equivalence class walking speed were not significantly associated with heart failure, but dose-response relationship exercise training number of studies was low.
For total physical activity, leisure-time activity, and vigorous activity the inverse associations were most pronounced at lower levels of activity, while for cardiorespiratory fitness a threshold effect was observed from around 12 METs at the exercise test. Increasing compliance with the recommendations for leisure-time activity was also dose-response relationship exercise training with a reduced risk of heart failure.
The inverse association between how to create a line graph in excel 2021 activity and heart failure was consistent across ethnic groups. Our findings are largely consistent with those of two previous meta-analyses [ 910 ], however, one of these did not conduct dose—response meta-analyses [ 10 ] and neither of them investigated specific domains of physical activity or potential effect modification by ethnicity.
Although much is unknown regarding the biologic mechanisms that could explain the observed inverse association between physical activity and heart failure, both dose-response relationship exercise training and direct effects may contribute. Physical activity could reduce the risk of heart failure indirectly by improving body weight control and lowering risk of overweight and obesity and weight gain [ 646566 ], improving insulin sensitivity [ 67 ] and lowering the risk of type 2 diabetes [ 56 ], reducing blood pressure and the risk of hypertension [ 66686970 ], and lowering resting heart rate [ 66 ] and reducing the risk of coronary heart disease [ 71 ], as all these risk factors are associated with increased risk of heart failure [ 5672 ].
However, in the current meta-analysis, there was little difference in the results between subgroups of studies that adjusted for BMI, diabetes and hypertension and those that did not. Also, two previous studies that made adjustments for BMI in a separate step within the same datasets found little difference in the results [ 1318 ]. This suggests that most dose-response relationship exercise training the association is independent of adiposity.